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Evaluation of a casein and a whey hydrolysate for treatment of cow's-milk-sensitive enteropathy

Abstract

A casein and a whey hyrolysate were evaluated in the management of 18 children with cow's-milk-sensitive enteropathy. This diagnosis was based upon clinical features, an abnormal small intestinal mucosa, i.e. an enteropathy, and a clinical response to cow's milk elimination. Two infants refused to take the whey hydrolysate. The median weight gain was higher in children given whey hydrolysate (19.4 g/day) than the casein hydrolysate (9.8 g/day). All children responded to cow's milk elimination and most has a significant improvement in small intestinal morphology after a cow's-milk-free diet. There was some advantage for the whey hydrolysate on morphometric analysis of their small intestinal mucosal response.

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Abbreviations

CD:

crypt zone depth

IEL:

intra-epithelial lymphocyte

TT:

total mucosal thickness

VH:

villous height

VH/CD:

villous height/crypt zone depth ratio

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Walker-Smith, J.A., Digeon, B. & Phillips, A.D. Evaluation of a casein and a whey hydrolysate for treatment of cow's-milk-sensitive enteropathy. Eur J Pediatr 149, 68–71 (1989). https://doi.org/10.1007/BF02024340

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  • DOI: https://doi.org/10.1007/BF02024340

Key Words

  • Cow's-milk-sensitive enteropathy
  • Whey hydrolysate
  • Casein hydrolysate
  • Morphometry