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Agents and Actions

, Volume 10, Issue 1–2, pp 165–166 | Cite as

Cardiovascular and behavioural changes after i.c.v. infusions of histamine and agonists in conscious goat

  • Leena Tuomisto
  • Lea Eriksson
Histamine and Kinins Histamine and the Cardiovascular System

Abstract

Histamine (3 and 10 μmoles) raised the blood pressure in the conscious goat when given i.c.v. but lowered it when given intravenously. The results with 2-PEA support the view that central H1-stimulation raises the blood pressure. However, the results with dimaprit do not exclude the participation of central H2-receptors in the effect of histamine on the blood pressure.

It appears that in the goat the stimulation of central H1- and H2-receptors mediates opposite actions on behaviour. H1-agonist increased and H2-agonist decreased the general activity of the animal.

Keywords

Blood Pressure Histamine General Activity Behavioural Change Opposite Action 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

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    U. Trendelenburg,Stimulation of Sympathetic Centers by Histamine, Circ. Res.5, 105 (1957).PubMedGoogle Scholar
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    P.E. Hicks,Central Cardiovascular Actions of Histamine in Rats: Involvement of histamine H 2-Receptors, Clin. Exp. Hypertension1, 251 (1978).Google Scholar
  3. [3]
    J.-C. Schwartz,Histaminergic Mechanisms in Brain, Ann. Rev. Pharmac. Toxicol.17, 325 (1977).CrossRefGoogle Scholar
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    B. Andersson, K. Olsson andR.G. Warner,Dissimilarities between the Central Control of Thirst and the Release of Antidiuretic Hormone (ADH), Acta Physiol. Scand.71, 57 (1967).PubMedGoogle Scholar

Copyright information

© Birkhäuser Verlag 1980

Authors and Affiliations

  • Leena Tuomisto
    • 1
    • 2
  • Lea Eriksson
    • 1
    • 2
  1. 1.Department of PharmacologyUniversity of HelsinkiHelsinkiFinland
  2. 2.Department of PhysiologyCollege of Veterinary MedicineHelsinkiFinland

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