Cardiovascular and behavioural changes after i.c.v. infusions of histamine and agonists in conscious goat
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Histamine (3 and 10 μmoles) raised the blood pressure in the conscious goat when given i.c.v. but lowered it when given intravenously. The results with 2-PEA support the view that central H1-stimulation raises the blood pressure. However, the results with dimaprit do not exclude the participation of central H2-receptors in the effect of histamine on the blood pressure.
It appears that in the goat the stimulation of central H1- and H2-receptors mediates opposite actions on behaviour. H1-agonist increased and H2-agonist decreased the general activity of the animal.
KeywordsBlood Pressure Histamine General Activity Behavioural Change Opposite Action
- P.E. Hicks,Central Cardiovascular Actions of Histamine in Rats: Involvement of histamine H 2-Receptors, Clin. Exp. Hypertension1, 251 (1978).Google Scholar