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, Volume 10, Issue 1–2, pp 145–147 | Cite as

Are the anti-allergic actions of theophylline due to antagonism at the adenosine receptor

  • Bertil B. Fredholm
  • Anita Sydbom
Histamine and Kinins Histamine and Immunology

Abstract

Adenosine potentiated anaphylactic histamine release from isolated rat mast cells in a dose-dependent manner between 10−8 and 10−5M. Adenosine was found to be present during a normal incubation of mast cells, but the concentration was low (2×10−8M). In rat plasma the concentration was 1.5×10−7M. The effect of 10−5M adenosine was dose-dependently inhibited by theophylline. 50% inhibition was found at 3×10−5M theophylline. Cyclic nucleotide phosphodiesterase inhibition required much higher concentrations (IC50∼10−3M). It is suggested that some of the anti-allergic actions of theophylline (clinical concentration range: 10−5–10−4M) does not involve cyclic nucleotides but may be due to inhibition of the effects of endogenous adenosine.

Keywords

Adenosine Mast Cell Histamine Theophylline Phosphodiesterase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser Verlag 1980

Authors and Affiliations

  • Bertil B. Fredholm
    • 1
  • Anita Sydbom
    • 1
  1. 1.Department of PharmacologyKarolinska InstitutetStockholmSweden

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