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Variations in levels of cyclic AMP and GMP in the thymus, spleen and mesenteric lymph node of rats after the induction of adjuvant arthritis

  • Histamine and Kinins Immunosuppression and Inflammation
  • Cyclic Nucleotides and Cellular Secretion
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Abstract

The development of adjuvant arthritis induced important modifications in intracellular levels of cyclic AMP and GMP in primary and secondary lymphoid organs: a continuous decrease in cyclic AMP and a biphasic increase in the level of cyclic GMP which correlate well with the onset of the acute phase and the systemization of the disease.

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Authors and Affiliations

  1. Département de Pharmacologie, ERA No 629 du CNRS, Hôpital Cochin, 27 rue du Faubourg Saint-Jacques, 75014, Paris, France

    M. Tissot & J. P. Giroud

  2. Laboratoire d'Adaptation Energétique à l'environnement, Collège de France, 11 place Marcelin Berthelot, 75005, Paris, France

    R. Bertin & R. Portet

Authors
  1. M. Tissot
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  2. R. Bertin
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  3. R. Portet
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  4. J. P. Giroud
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Tissot, M., Bertin, R., Portet, R. et al. Variations in levels of cyclic AMP and GMP in the thymus, spleen and mesenteric lymph node of rats after the induction of adjuvant arthritis. Agents and Actions 10, 563–565 (1980). https://doi.org/10.1007/BF02024167

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  • DOI: https://doi.org/10.1007/BF02024167

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