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Lipoxygenase products and the polymorphonuclear leucocyte

  • Histamine and Kinins Immunosuppression and Inflammation
  • Lipoxygenase Products: Release and Activities
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Abstract

Polymorphonuclear leucocytes (PMNs), when exposed to the calcium ionophore A23187, release into the supernatant a substance that causes the aggregation and chemokinesis of fresh PMN suspensions. Release of these activities is inhibited by preincubation with drugs known to inhibit lipoxygenase pathways of arachidonic acid metabolism but is unaffected by cyclooxygenase inhibitors. The substance responsible for these activities has been identified as leukotriene B and this compound has been shown to be a potent chemokinetic and aggregatory agent for PMNs over the range 10 pg to 5 ng ml−1.

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Authors and Affiliations

  1. Department of Chemical Pathology, King's College Hospital Medical School, Denmark Hill, SE5 8RX, London, UK

    A. W. Ford-Hutchinson, M. A. Bray & M. J. H. Smith

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  1. A. W. Ford-Hutchinson
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  2. M. A. Bray
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  3. M. J. H. Smith
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Ford-Hutchinson, A.W., Bray, M.A. & Smith, M.J.H. Lipoxygenase products and the polymorphonuclear leucocyte. Agents and Actions 10, 548–550 (1980). https://doi.org/10.1007/BF02024162

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  • DOI: https://doi.org/10.1007/BF02024162

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