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, Volume 10, Issue 6, pp 522–527 | Cite as

A superoxide-activated chemotactic factor and its role in the inflammatory process

  • M. McCord
Histamine and Kinins Immunosuppression and Inflammation Oxygen Free Radicals: Release and Activities


Superoxide dismutase or derivatives thereof have been shown to be potent anti-inflammatory agents in several models of induced inflammation. In all cases, the anti-inflammatory effects included a marked suppression of the accumulation of inflammatory cells at the site of the potential lesion, suggesting a role for the superoxide radical in the chemotaxis process. The exposure of normal plasma to a source of superoxide in vitro resulted in the formation of a powerful chemotactic factor for human neutrophils. The factor is activated by reacting specifically with superoxide, and was found to consist of a complex of serum albumin and an unidentified lipid. The complex may be resolved and reconstituted. Both components are required for expression of biologic activity. The major mechanism for the anti-inflammatory activity of superoxide dismutase appears to be the prevention of the formation of this plasma-derived superoxide-dependent chemotactic factor.


Lipid Albumin Superoxide Serum Albumin Inflammatory Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Birkhäuser-Verlag 1980

Authors and Affiliations

  • M. McCord
    • 1
  1. 1.Department of BiochemistryUniversity of South AlabamaMobileUSA

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