Agents and Actions

, Volume 9, Issue 1, pp 49–52 | Cite as

Comparison of alterations in the histamine-diamine oxidase system during acute intestinal ischaemia in pigs, dogs and rabbits: Evidence for a uniform pathophysiological mechanism?

  • J. Kusche
  • C. D. Stahlknecht
  • W. Lorenz
  • G. Reichert
  • W. Dietz
European Branch of Histamine Club Seventh Annual Meeting, May 2–4 1978, Łódź (Poland) Histamine Metabolism


Pathophysiological Mechanism Intestinal Ischaemia Oxidase System Acute Intestinal Ischaemia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Diamine oxidase (amine: oxygen oxidoreductase (deaminating) (pyridoxal-containing) (E.C.




superior mesenteric artery occlusion


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  1. [1]
    W. Lorenz, L. Benesch, H. Barth, E. Matejka, R. Meyer, J. Kusche, M. Hutzel andE. Werle,Fluorometric Assay of Histamine in Tissues and Body Fluids: Choice of the Purification Procedure and Identification in the Nanogram Range, Z. anal. Chem.252, 94 (1970).CrossRefGoogle Scholar
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    J. Kusche, H. Richter, R. Hesterberg, J. Schmidt andW. Lorenz,Comparison of the 14 C-Putrescine Assay with the NADH Test of the Determination of Diamine Oxidase: Description of a Standard Procedure with a High Precision and Improved Accuracy. Agents and Actions3, 148 (1973).CrossRefPubMedGoogle Scholar
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    W. Lorenz, H. Barth, M. Thermann, A. Schmal, P. Dormann andI. Niemeyer,Fluorometric Histamine Determination in Canine Plasma Under Normal Conditions Following Application of Exogenous Histamine and During Histamine Release by Haemaccel, Hoppe-Seyler's Z. Physiol. Chem.355, 1097 (1974).PubMedGoogle Scholar
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    J. Kusche, H. Richter, J. Schmidt, R. Hesterberg, A. Friedrich andW. Lorenz,Diamine Oxidase in Rabbit Small Intestine: Separation from a Soluble Monoamine Oxidase, Properties and Pathophysiological Significance in Intestinal Ischemia, Agents and Actions 5, 431 (1975).CrossRefPubMedGoogle Scholar
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    J. Kusche, C.-D. Stahlknecht, W. Lorenz, G. Reichert andH. Richter,Diamine Oxidase and Histamine Release in Dogs Following Acute Mesenteric Artery Occlusion, Agents and Actions7, 81 (1977).CrossRefPubMedGoogle Scholar
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    H. Richter, J. Kusche, W. Lorenz, M. Thermann, H.-J. Reimann, R. Hesterberg, J. Schmidt andA. Friedrich,Diamine Oxidase as a Protective Factor in Intestinal Ischemia: Dose-related Shortening of Survival Time Following Injection of Aminoguanidine, Gastroenterology (submitted for publication).Google Scholar
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    W. Lorenz andA. Doenicke,Anaphylactoid Reactions and Histamine Release by Intravenous Drugs Used in Surgery and Anaesthesia, in:Adverse Response to Intravenous Drugs (Academic Press, New York, 1978, p. 83).Google Scholar
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    W. Lorenz, H. Barth, J. Kusche, H.-J. Reimann, A. Schmal, E. Matejka, Ch. Mathias, M. Hutzel andE. Werle,Histamine in the Pig. Determination, Distribution, Release and Pharmacological Actions, Eur. J. Pharmacol.14, 155 (1971).CrossRefPubMedGoogle Scholar
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    H. Richter, J. Kusche, K.-Th. Schumann, J. Schmidt andW. Lorenz,Diaminoxydase, Histamin und Histidin im Dünndarm nach experimenteller Ischämie, Langenbecks Arch. Chir. Suppl. Chir. Forum 295 (1973).Google Scholar
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    W. Lorenz, A. Doenicke, R. Meyer, H.-J. Reimann, J. Kusche, H. Barth, H. Geesing, M. Hutzel andB. Weissenbacher,An Improved Method for the Determination of Histamine Release in Man: Its Application in Studies with Propanidid and Thiopentone, Eur. J. Pharmacol.19, 180 (1972).CrossRefPubMedGoogle Scholar
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    W. Lorenz, E. Hell, O. Boeckl, H.-J. Reimann, G. Zimmermann, W. Seidel, M. Laszcz andR. Uhlig,Histamine Release During Orthotopic Homologous Liver Transplantation in Pigs, Eur. Surg. Res.5, 11 (1973).PubMedGoogle Scholar
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    J. Kusche, W. Lorenz, C.-D. Stahlknecht, A. Friedrich, A. Schmidt, K. Boo andG. Reichert,Diamine Oxidase in Gastric and Duodenal Mucosa of Man and Other Mammals with Special Reference to the Pyloric Junction, Agents and Actions8, 366 (1978).CrossRefPubMedGoogle Scholar
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    W. Lorenz, E. Matejka, A. Schmal, W. Seidel, H.-J. Reimann, R. Uhlig andG. Mann,A Phylogenetic Study on the Occurrence and Distribution of Histamine in the Gastrointestinal Tract and Other Tissues of Man and Various Animals, Comp. gen. Pharmac.4, 229 (1973).CrossRefGoogle Scholar
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    W.J. Burdette andE.A. Gehan,Planning and Analysis of Clinical Studies, (Charles C. Thomas, 1970), p. 73.Google Scholar

Copyright information

© Birkhäuser-Verlag 1979

Authors and Affiliations

  • J. Kusche
    • 1
  • C. D. Stahlknecht
    • 1
  • W. Lorenz
    • 1
  • G. Reichert
    • 1
  • W. Dietz
    • 1
  1. 1.Division of Experimental Surgery and Pathological Biochemistry and Division of General Surgery, Department of SurgeryUniversity of D-3550 Marburg/LahnWest Germany

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