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, Volume 9, Issue 1, pp 29–30 | Cite as

Blockade by cimetidine of the effects of histamine on adenylate cyclase activity, spontaneous rate and contractility in the developing praenatal heart

  • Mária Wollemann
  • J. Gy Papp
European Branch of Histamine Club Seventh Annual Meeting, May 2–4 1978, Łódź (Poland) Histamine Receptors

Conclusions

The results support the view that in man cardiac responsiveness to histamine appears at a very early stage of development. It might also be suggested that in human embryonic and foetal hearts the adenylate cyclase activating, positive chronotropic and ventricular inotropic effects of histamine are mediated via H2-type histaminergic receptors.

Keywords

Histamine Cimetidine Adenylate Cyclase Foetal Heart Cyclase Activate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. [1]
    G.C. Palmer andW.G. Dail Jr., Pediat. Res.9, 98 (1975).PubMedGoogle Scholar
  2. [2]
    J. Gy. Papp andB.A. Resch, Naunyn-Schmiedeberg's Arch. Pharmacol.285, R 61 (1974).Google Scholar
  3. [3]
    K.W. Brimblecombe, W.A.M. Duncan, G.J. Durant, C. Emmet, C.R. Ganellin andM.E. Parsons, J. Intern. Med. Res.3, 86 (1975).Google Scholar
  4. [4]
    Mária Wollemann, J. Borbola, J. Gy. Papp andL. Szekeres, J. Mol. Cell Cardiol.7, 523 (1975).CrossRefPubMedGoogle Scholar

Copyright information

© Birkhäuser-Verlag 1979

Authors and Affiliations

  • Mária Wollemann
    • 1
  • J. Gy Papp
    • 1
  1. 1.Institute of BiochemistryBiological Research Center of the Hungarian Academy of Sciences and Department of Pharmacology, University Medical SchoolSzegedHungary

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