Blockade by cimetidine of the effects of histamine on adenylate cyclase activity, spontaneous rate and contractility in the developing praenatal heart
European Branch of Histamine Club Seventh Annual Meeting, May 2–4 1978, Łódź (Poland) Histamine Receptors
The results support the view that in man cardiac responsiveness to histamine appears at a very early stage of development. It might also be suggested that in human embryonic and foetal hearts the adenylate cyclase activating, positive chronotropic and ventricular inotropic effects of histamine are mediated via H2-type histaminergic receptors.
KeywordsHistamine Cimetidine Adenylate Cyclase Foetal Heart Cyclase Activate
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
andW.G. Dail Jr.
, Pediat. Res.9
, 98 (1975).PubMedGoogle Scholar
J. Gy. Papp
, Naunyn-Schmiedeberg's Arch. Pharmacol.285
, R 61 (1974).Google Scholar
K.W. Brimblecombe, W.A.M. Duncan, G.J. Durant, C. Emmet, C.R. Ganellin
, J. Intern. Med. Res.3
, 86 (1975).Google Scholar
Mária Wollemann, J. Borbola, J. Gy. Papp
, J. Mol. Cell Cardiol.7
, 523 (1975).CrossRefPubMedGoogle Scholar