Agents and Actions

, Volume 9, Issue 1, pp 15–17 | Cite as

Effect of ergometrine on contractile force of guinea-pig isolated heart: Antagonism by cimetidine

  • S. Bongrani
  • M. Di Donato
  • O. Visioli
  • P. Mantovani
Histamine and Kinins


The action of ergometrine on contractile force of guinea-pig isolated heart was investigated and the effect of receptor antagonists on the inotropic effect of ergometrine, isoproterenol, dopamine and histamine was evaluated. Ergometrine was found to have a good dose-dependent inotropic effect and the antagonism of cimetidine toward this action is reported. Experiments carried out in hearts in which a massive depletion of mast-cells histamine was produced are in favour of a direct action of the drug on H2-receptors.


Dopamine Receptor Antagonist Histamine Cimetidine Direct Action 
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Copyright information

© Birkhäuser-Verlag 1979

Authors and Affiliations

  • S. Bongrani
    • 1
  • M. Di Donato
    • 1
  • O. Visioli
    • 1
  • P. Mantovani
    • 2
  1. 1.Chair of Cardiovascular DiseasesUniversity of ParmaParmaItaly
  2. 2.Institute of PharmacologyUniversity of FlorenceItaly

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