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, Volume 9, Issue 1, pp 15–17 | Cite as

Effect of ergometrine on contractile force of guinea-pig isolated heart: Antagonism by cimetidine

  • S. Bongrani
  • M. Di Donato
  • O. Visioli
  • P. Mantovani
Histamine and Kinins

Abstract

The action of ergometrine on contractile force of guinea-pig isolated heart was investigated and the effect of receptor antagonists on the inotropic effect of ergometrine, isoproterenol, dopamine and histamine was evaluated. Ergometrine was found to have a good dose-dependent inotropic effect and the antagonism of cimetidine toward this action is reported. Experiments carried out in hearts in which a massive depletion of mast-cells histamine was produced are in favour of a direct action of the drug on H2-receptors.

Keywords

Dopamine Receptor Antagonist Histamine Cimetidine Direct Action 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser-Verlag 1979

Authors and Affiliations

  • S. Bongrani
    • 1
  • M. Di Donato
    • 1
  • O. Visioli
    • 1
  • P. Mantovani
    • 2
  1. 1.Chair of Cardiovascular DiseasesUniversity of ParmaParmaItaly
  2. 2.Institute of PharmacologyUniversity of FlorenceItaly

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