Agents and Actions

, Volume 9, Issue 1, pp 15–17 | Cite as

Effect of ergometrine on contractile force of guinea-pig isolated heart: Antagonism by cimetidine

  • S. Bongrani
  • M. Di Donato
  • O. Visioli
  • P. Mantovani
Histamine and Kinins


The action of ergometrine on contractile force of guinea-pig isolated heart was investigated and the effect of receptor antagonists on the inotropic effect of ergometrine, isoproterenol, dopamine and histamine was evaluated. Ergometrine was found to have a good dose-dependent inotropic effect and the antagonism of cimetidine toward this action is reported. Experiments carried out in hearts in which a massive depletion of mast-cells histamine was produced are in favour of a direct action of the drug on H2-receptors.


Dopamine Receptor Antagonist Histamine Cimetidine Direct Action 


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  1. [1]
    C.B. Higgins, L. Wexler, J. Silverman, W.G. Hayden, W.L. Anderson andJ.H. Schroeder,Spontaneously and Pharmacologically Provoked Coronary Arterial Spasm in Prinzmetal Variant Angina, Radiology119, 521 (1976).PubMedGoogle Scholar
  2. [2]
    G.L. Brown andH.H. Dale,The Pharmacology of Ergometrine, Proc. roy. Soc. Series B118, 446 (1935).Google Scholar
  3. [3]
    I.R. Inness,Identification of the Smooth Muscle Excitatory Receptors for Ergot Alkaloids, Br. J. Pharmacol.19, 120 (1962).Google Scholar
  4. [4]
    M.R. Wassef, H. Lal andB.J. Pleuvry,The Cardiovascular Effects of Ergometrine in the Experimental Animal in vivo and in vitro. Br. J. Anaesth.46, 473 (1974).PubMedGoogle Scholar
  5. [5]
    G.N. Woodruff,Dopamine Receptors: A Review, Comp. gen. Pharmac.2, 439 (1971).CrossRefGoogle Scholar
  6. [16]
    A. Mugelli, F. Ledda, L. Mantelli, M. Torrini andT. Maccioni,Studies on the Positive Inotropic Effect of Dopamine in the Guinea Pig Heart, Arch. Pharmacol.301, 49 (1977).CrossRefGoogle Scholar
  7. [7]
    A. Giotti, A. Guidotti, P.F. Mannaioni andL. Zilletti,The Influence of Adrenotropic Drugs and Noradrenaline on the Histamine Release in Cardiac Anaphylaxis in vitro. J. Physiol.184, 924 (1966).PubMedGoogle Scholar

Copyright information

© Birkhäuser-Verlag 1979

Authors and Affiliations

  • S. Bongrani
    • 1
  • M. Di Donato
    • 1
  • O. Visioli
    • 1
  • P. Mantovani
    • 2
  1. 1.Chair of Cardiovascular DiseasesUniversity of ParmaParmaItaly
  2. 2.Institute of PharmacologyUniversity of FlorenceItaly

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