Summary
Various membrane transport functions have been studied in erythrocytes from essential fatty acid (EFA) deficient rats in order to determine whether or not functional abnormalities induced by documented EFA-deficiency of the membrane could be demonstrated. No differences were found between EPA deficient and control cells with respect to mean values for osmotic resistance or intracellular sodium and potassium concentrations. However, uptake of leucine by EFA deficient erythrocytes was significantly greater than that of control erythrocytes. Kinetic studies suggest that EFA deficiency enhances the passive diffusion component of this transport.
Zusammenfassung
An Erythrozyten von Ratten mit essentiellem Fettsäuremangel wurden verschiedene Transportfunktionen der Membran studiert, um zu klären, ob ein Mangel an essentiellen Fettsäuren in der Erythrozytenmembran zu funktionellen Veränderungen führt. Im Vergleich zu Kontrolltieren konnte bezüglich nachfolgender Parameter kein signifikanter Unterschied gefunden werden: osmotische Resistenz; intrazelluläre Natrium- und Kaliumkonzentration.
Die Aminosäure Leuzin wurde jedoch von Erythrozyten mit essentiellem Fettsäuremangel signifikant vermehrt aufgenommen als von Erythrozyten der Kontrolltiere. Kinetische Untersuchungen stützen die Vermutung, daß essentieller Fettsäuremangel die passive Komponente des Transportes verstärkt.
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This research was supported by a grant from the National Institute of Health (HD-08432)
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Böhles, H., Nicholson, J.F., Heird, W.C. et al. Effects of essential fatty acid deficiency on various functions of the rat erythrocyte membrane. Z Ernährungswiss 18, 112–118 (1979). https://doi.org/10.1007/BF02023725
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DOI: https://doi.org/10.1007/BF02023725