Skip to main content
Log in

Secretion pattern of retinol-binding protein in blood of goats: Effect of vitamin A, provitamin A and their dosing schedule

  • Original Contributions
  • Published:
Zeitschrift für Ernährungswissenschaft Aims and scope Submit manuscript

Summary

Studies were conducted on the secretion of retinol-binding protein (RBP) in blood of goats given different treatments of preformed vitamin A, Β-carotene and plant carotenoids. Administration of these sources either in a single massive dose or massive dose split into four equal doses, markedly increased the secretion of RBP in blood. The secretion of RBP in blood occurred at least in two phases, one at early periods and the other at later periods.

Zusammenfassung

Die Sekretion von retinolbindendem Protein (RBP) ins Blut von Ziegen wurde nach unterschiedlicher Verabreichung von Vitamin A (Retinylacetat), Β-Carotin und einer Mischung von pflanzlichen Carotinoiden untersucht. Die Zufuhr dieser Verbindungen — entweder in einer einzelnen hohen Dosis oder in der gleichen Menge gleichmäßig auf 4 Tagesdosen verteilt — führte zu einem deutlichen Anstieg der RBP-Sekretion. Diese Sekretion erfolgte in zwei Phasen, von denen eine früh und eine später einsetzte.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Goodman DS (1980) Vitamin A metabolism. Fed Proc 39:2716

    CAS  Google Scholar 

  2. Goodman DS, Blaner WS (1984) In: Sporn MB, Roberts AB, Goodman DS (eds) The retinoids. Academic Press, Orlando, FL, vol 2, pp 2–34

    Google Scholar 

  3. Kanai M, Raz A, Goodman DS (1968) Retinol-binding protein: The transport protein for vitamin A in human plasma. J Clin Invest 47:2025–2044

    Article  CAS  Google Scholar 

  4. Bashor MM, Chytil F (1975) Cellular retinol binding protein. Biochem Biophys Acta 411:87–96

    Article  CAS  Google Scholar 

  5. Fex G, Johanneson G (1982) Purification and partial characterization of a cellular retinol binding protein from human liver. Biochem Biophys Acta 714:536–542

    Article  CAS  Google Scholar 

  6. Goyal KC, Sharma YK, Misra UK (1987) Isolation and purification of cellular retinol binding protein (CRBP) from goat mammary gland. Life Scs 40:863–870

    Article  CAS  Google Scholar 

  7. Muto Y, Smith JE, Milch PO, Goodman DS (1972) Regulation of retinol binding protein metabolism by vitamin A status in the rat. J Biol Chem 247:2542–2550

    CAS  Google Scholar 

  8. Smith FR, Goodman DS, Zaklama MS, Gahr MK, Maraghy SE, Patwardhan VN (1972) Serum vitamin A, retinol binding protein and prealbumin concentrations in protein calorie malnutrition IA functional defect in hepatic retinol release. Amer J Clin Nutr 26:973–976

    Google Scholar 

  9. Muhilal H, Glover J (1974) Effects of dietary deficiencies of protein and retinol on the plasma level of retinol binding protein in rat. Brit J Nutr 32:549–558

    Article  CAS  Google Scholar 

  10. Britton G, Goodwin TW (1971) Biosynthesis of carotenoids. Meths Enzymol vol XVIII, part C

  11. Goyal KC, Sharma YK, Misra UK (1984) Effect of carotenoid isolates from green leaves on the growth and hepatic vitamin A levels of vitamin A deficient chicks. Nutr Reports Internat (USA) 29:1155–1160

    CAS  Google Scholar 

  12. IVACG report (1979) Recent advances in the metabolism and function of vitamin A and their relationship to applied nutrition VI. A report of International Vitamin A Consultative Group

  13. Laurell CB (1966) Quantitation estimation of proteins by electrophoresis in agarose gel containing antibodies. Anal Biochem 15:45–52

    Article  CAS  Google Scholar 

  14. Goyal KC, Sharma YK, Chaudhary VK, Misra UK (1984) An improved method for the isolation of retinol binding protein from goat serum. Ind J Biochem Biophys 21:59–61

    CAS  Google Scholar 

  15. Sharma YK, Goyal KC, Misra UK (1983) Vitamin A and RBP contents of goats given a single massive dose of vitamin A orally. Nutr Reports Internat (USA) 28:593–596

    CAS  Google Scholar 

  16. Sunderessan PR (1977) Rate of metabolism of retinol in retinoic acid maintained rats after a single dose of radioactive retinol. J Nutr 107:70–75

    Google Scholar 

  17. Bhat PV, Lacroix A (1983) Metabolism of 11-3H-retinyl acetate in liver tissue of vitamin A sufficient, -deficient and retinoic acid supplemented rats. Biochem Biophys Acta 752:451–455

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Goyal, K.C., Sharma, Y.K., Sharma, H.S. et al. Secretion pattern of retinol-binding protein in blood of goats: Effect of vitamin A, provitamin A and their dosing schedule. Z Ernährungswiss 28, 225–230 (1989). https://doi.org/10.1007/BF02023692

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02023692

Key words

Schlüsselwörter

Navigation