Summary
The fatty-acid composition of red-cell-membrane phospholipids (total phospholipids, phosphatidylcholine, and phosphatidylethanolamine fractions) was determined in 88 apparently healthy children aged 1 to 15 years, 10 cord blood samples, and 6 infants below 1 year of age.
The major aim of the study was to determine the normal ranges of fatty-acid proportions, including trans- and odd-numbered fatty acids, for further studies of nutritional and metabolic disorders.
The concentrations of most fatty acids of the phospholipids analyzed increased or decreased after birth and assumed adult levels before the second year of life. α-linolenic acid (C18∶3n-3) and trans fatty acids, however, continued to increase with age until late childhood.
Zusammenfassung
Bei insgesamt 88 gesunden Kindern im Alter zwischen 1 und 15 Jahren, 6 Kindern unter einem Jahr und in 10 Nabelschnurblutproben wurde die Fettsäurenzusammensetzung der Phospholipide (Gesamt-Phospholipide, Phosphatidylethanolamin, Phosphatidylcholin) untersucht. Ziel der Arbeit war es, altersabhängige Normbereiche für die prozentuale Fettsäurenverteilung einschlie\lich der Trans-Fettsäuren und der ungeradzahligen Fettsäuren zu erstellen, als Grundlage für weitere Untersuchungen bei Ernährungsstörungen und Stoffwechselkrankheiten. Die untersuchten Phospholipide wiesen besonders im 1. Lebensjahr deutliche Veränderungen in der Fettsäurenverteilung auf. Bis zu Beginn des 2. Lebensjahres bildete sich ein „adultes“ Muster heraus. Lediglich die prozentualen Anteile der α-Linolensäure (18∶3n-3) und die der Trans-Fettsäuren stiegen weiter bis zur zweiten Lebensdekade an.
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Laryea, M., Cieslicki, P., Diekmann, E. et al. Age-dependent fatty acid composition of erythrocyte membrane phospholipids in healthy children. Z Ernährungswiss 29, 284–294 (1990). https://doi.org/10.1007/BF02023085
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DOI: https://doi.org/10.1007/BF02023085