Late and acute adverse reactions to iohexol in a pediatric population
- 39 Downloads
The purpose of this study was to determine the incidence of acute and late reactions after contrastmedium injection in the Finnish paediatric population. From March 1989 to November 1990, 321 children under 19 years of age were examined with a nonionic contrast medium, iohexol, for urography and CT. The follow-up time for late reactions was up to 24 h after the contrast-medium injection. The return rate for the questionnaires given to patients to record their reactions was 73.2%. Acute adverse reaction was noted in 1.9% of the patients, with the most frequent reactions being in the weight range 24–40 kg. Asthma and previous reactions to contrast medium are risk factors for acute reaction. Late reactions were found in 6.2% of the patients, most frequently in children weighing under 24 kg.
KeywordsPublic Health Asthma Contrast Medium Adverse Reaction Paediatric Population
Unable to display preview. Download preview PDF.
- 10.Beyer-Enke SA, Zeitler E (1993) Late adverse reactions to nonionic contrast media: a cohort analytic study. Eur Radiol 3: 237–241Google Scholar
- 12.Hartwig P, Mützel W, Taenzer V (1989) Pharmacokinetics of iohexol, iopamidol, iopromide and iosimide compared with meglumine diatrizoate. In: Taenzer V, Wende S (eds) Recent developments in nonionic contrast media. Thieme, New York, pp 220–223Google Scholar
- 13.Mützel W, Nagel R, Kemper JD, Clauß W (1984) Pharmakokinetik des nichtionischen Röntgenkontrastmittels Ihexol. Aktuel Urol 15: 154–156Google Scholar
- 14.Aakhus T, Sommerfelt C, Stormorken H, et al. (1980) Tolerance and excretion of iohexol after intravenous injection in healthy volunteers. Preliminary report. Acta Radiol Suppl 362: S131-S134Google Scholar
- 16.Lasser E (1985) Etiology of anaphylactoid responses. The promise of nonionics. Invest Radiol 20: S80-S83Google Scholar
- 17.Fisher HW (1988) Adverse reactions. In: Carr DH (ed) Contrast media. Churchill Livingstone, New York, pp 24–37Google Scholar
- 19.Bolz KD, Skalpe IO, Gurreberg TJ (1984) Iohexol and metrizoate in urography in children. Comparison between a non-ionic and ionic contrast medium. Acta Radiol 25: 155–158Google Scholar
- 22.Shehadi WH (1985) Death following intravascular administration of contrast media. Acta Radiol Diagn 26: 457–461Google Scholar