Pediatric Radiology

, Volume 25, Issue 1, pp 7–11 | Cite as

Central precocious puberty: Evaluation by neuroimaging

  • L. Kornreich
  • G. Horev
  • S. Blaser
  • D. Daneman
  • R. Kauli
  • M. Grunebaum


To evaluate the incidence of abnormal intracranial findings in children with central precocious puberty, 62 children (51 girls, 11 boys) were examined by computerized tomography and/or magnetic resonance imaging (MRI) of the brain. Forty-four had normal examinations; 18 (11 girls, 7 boys) showed intracranial pathologies, including hamartoma of the tuber cinereum (8 cases), parenchymal loss (3 cases), hypothalamicchiasmatic lesions (2 cases), lesions of the corpus callosum (2 cases), suprasellar cyst (1 case), and pineal cyst and mesiotemporal sclerosis (1 case each). Based on the correlation between the clinical and the imaging results of this series, the authors recommend MRI as the imaging method of choice in the investigation of precocious puberty.


Public Health Computerize Tomography Magnetic Resonance Imaging Corpus Callosum Imaging Method 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Kulin HE (1989) Disorders of sexual maturation: delayed adolescence and precocious puberty. In: De Groot LJ (ed) Endocrinology. Saunders, Philadelphia, 1886Google Scholar
  2. 2.
    Wheeler MD, Styne DM (1990) Diagnosis and management of precocious puberty. Pediatr Clin North Am 37:1255PubMedGoogle Scholar
  3. 3.
    Rieth KG, Comite F, Dweyer AJ et al (1987) CT of cerebral abnormalities in precocious puberty. AJR 148:1231PubMedGoogle Scholar
  4. 4.
    Odel WD (1989) Puberty. In: De Groot LJ (ed) Endocrinology. Saunders, Philadelphia, p 1860Google Scholar
  5. 5.
    Greulich WW, Pyle SI (1959) Radiographic atlas of skeletal development of the hand and wrist Stanford University Press, StanfordGoogle Scholar
  6. 6.
    Kuzniecky R, De la Sayette V, Ethier R et al. (1987) Magnetic resonance imaging in temporal lobe epilepsy: pathological correlation. Ann Neurol 22:341CrossRefPubMedGoogle Scholar
  7. 7.
    Rosenfield RL (1991) Puberty and its disorders in girls. Endocrinol Metab Clin North Am 20:15PubMedGoogle Scholar
  8. 8.
    Boyko OB, Curnes JT, Oakes WJ, Burger PT (1991) Hamartoma of the tuber cinereum: CT, MR and pathologic findings. AJR 156:1053Google Scholar
  9. 9.
    Burton EM, Ball WS Jr, Crone K, Dolan LM (1989) Hamartoma of tuber cinereum: a comparison of MR and CT findings in four cases. AJNR 10:497PubMedGoogle Scholar
  10. 10.
    Lyon AJ, De Bruyn R, Grant DB (1985) Isosexual precocious puberty in girls. Acta Paediatr Scand 74:950PubMedGoogle Scholar
  11. 11.
    Smith PJ, Hindmarsh P, Kendall B, Brook CGD (1986) Dysgenesis of corpus callosum and hypopituitarism. Acta Paediatr Scand 75:923PubMedGoogle Scholar
  12. 12.
    Smirniotopoulos JG, Rushing EJ, Mena H (1992) From the archives of the AFIP pineal region masses differential diagnosis. Radiographics 12:577PubMedGoogle Scholar
  13. 13.
    Argyropoulou M, Perignon E, Brunelle F, Brouner R, Rapaport R (1991) Height of normal pituitary gland as a function of age evaluated by magnetic resonance in children. Pediatr Radiol 21:247CrossRefPubMedGoogle Scholar
  14. 14.
    Elster AD, Chen MYM, Williams DW III, Key LL (1990) Pituitary gland: MR imaging of physiologic hypertrophy in adolescence. Radiology 174:681PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • L. Kornreich
    • 1
    • 2
  • G. Horev
    • 1
    • 2
  • S. Blaser
    • 3
  • D. Daneman
    • 4
  • R. Kauli
    • 5
    • 6
  • M. Grunebaum
    • 1
    • 2
  1. 1.Department of Pediatric ImagingThe Children's Medical Center of IsraelPetah TiqvaIsrael
  2. 2.Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael
  3. 3.Department of RadiologyHospital for Sick ChildrenTorontoCanada
  4. 4.Division of Endocrinology, Department of PediatricsHospital for Sick ChildrenTorontoCanada
  5. 5.Institute of Pediatric and Adolescent Endocrinologythe Children's Medical Center of IsraelPetah TiqvaIsrael
  6. 6.Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael

Personalised recommendations