Experimental intraabdominal abscess formation byEscherichia coli andBacteroides fragilis
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An improved animal model of intraperitoneal abscess formation was developed in order to study the role ofBacteroides fragilis andEscherichia coli. Both microorganisms were found to independently cause abscesses, althoughBacteroides fragilis-induced abscesses were invariably minute. The combined inoculation of these microorganisms resulted in the induction of intraabdominal abscesses larger than those formed byBacteroides fragilis orEscherichia coli alone. However, the size difference between abscesses produced byEscherichia coli alone and by the combination of both organisms was not statistically significant. The animal model defined in this study differed from earlier models in that use of the complex sterile cecal contents can be avoided. This allows for a more precise evaluation of the contribution of each organism to the pathogenic process of intraabdominal abscess formation.
KeywordsInternal Medicine Animal Model Size Difference Early Model Abscess Formation
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