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Iron and host defence

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References

  1. Weinberg, E. D.: Iron and infection. Microbiological Reviews 1978, 42: 45–66.

    PubMed  Google Scholar 

  2. Higashi, O., Sato, Y., Takamatsu, H., Oyama, M.: Mean cellular peroxidase (MCP) of leukocytes iron deficiency anemia. Tohoku Journal of Experimental Medicine 1967, 93: 105–113.

    PubMed  Google Scholar 

  3. Hershko, C., Karsai, A., Eylon, L., Izak, G.: The effect of chronic iron deficiency on some biochemical functions of the human hemopoetic tissue. Blood 1970, 36: 321–330.

    PubMed  Google Scholar 

  4. Jacobs, A.: Tissue changes in iron deficiency. British Journal of Haematology 1969, 16: 1–4.

    PubMed  Google Scholar 

  5. Andelman, M. B., Sered, B. R.: Utilization of dietary iron by term infants. American Journal of Diseases of Children 1966, 111: 45–55.

    PubMed  Google Scholar 

  6. Buckley, R. H.: Iron deficiency anemia: its relationship to infection susceptibility and host defense. Journal of Pediatrics 1975, 86: 993–995.

    PubMed  Google Scholar 

  7. Lukens, J. N.: Iron deficiency and infection. American Journal of Diseases of Children 1975, 129: 160–162.

    PubMed  Google Scholar 

  8. Likhite, V., Rodvien, R., Crosby, W. H.: Depressed phagocytic function exhibited by polymorphonuclear leucocytes from chronically deficient rabbits. British Journal of Haematology 1976, 34: 251–255.

    PubMed  Google Scholar 

  9. Chandra, R. K.: Reduced bactericidal capacity of polymorphs in iron deficiency. Archives of Disease in Childhood 1973, 48: 864–866.

    PubMed  Google Scholar 

  10. MacDougall, L. G., Anderson, R., McNab, G. M., Katz, J.: Immune response in iron-deficient children. Impaired cellular mechanism with altered humoral components. Journal of Pediatrics 1975, 86: 833–843.

    PubMed  Google Scholar 

  11. Chandra, R. K., Saraya, A. K.: Impaired immunocompetence associated with iron deficiency. Journal of Pediatrics 1975, 86: 899–902.

    PubMed  Google Scholar 

  12. Srikantia, S. G., Prasad, J. S., Bhaskaram, C., Krishnamachari, K. A.: Anaemia and immune response. Lancet 1976, i: 1307–1309.

    Article  Google Scholar 

  13. Kulapongs, P., Vithayasi, V., Suskind, R., Olson, R. E.: Cell-mediated immunity and phagocytosis and killing function in children with severe iron-deficiency anaemia. Lancet 1974, ii: 689–691.

    Article  Google Scholar 

  14. Klebanoff, S. J.: Myeloperoxidase: contribution to the microbicidal activity of intact leukocytes. Science 1970, 169: 1095–1097.

    PubMed  Google Scholar 

  15. Katsushima, N.: Peroxidase content per single myeloid cell and in plasma. Its clinical significance in pediatrics. Tohoku Journal of Experimental Medicine 1963, 79: 250–266.

    Google Scholar 

  16. Prasad, J. S.: Leucocyte function in iron-deficiency anemia. American Journal of Clinical Nutrition 1979, 32: 550–552.

    PubMed  Google Scholar 

  17. Higgs, J. M., Wells, R. S.: Chronic mucocutaneous candidiasis: associated abnormalities of iron metabolism. British Journal of Dermatology 1973, 86, Supplement 8: 88–94.

    Google Scholar 

  18. Fletcher, J.: The effect of iron and transferrin on the killing ofEscherichia coli in fresh serum. Immunology 1971, 20: 493–498.

    PubMed  Google Scholar 

  19. Joynson, D. H. M., Walker, D. M., Jacobs, A., Dolby, A. E.: Defect of cell-mediated immunity in patients with iron-deficiency anaemia. Lancet 1972, ii: 1058–1059.

    Article  Google Scholar 

  20. Kuvibidila, S. R., Surendra, B., Suskind, M.: Effects of iron defiency anemia on delayed cutaneous hypersensitivity in mice. American Journal of Clinical Nutrition 1981, 34: 2635–2640.

    PubMed  Google Scholar 

  21. Nalder, B. N., Mahoney, A. W., Ramakrishnan, R., Hendricks, D. G.: Sensitivity of the immunological response to the nutritional status of rats. Journal of Nutrition 1972, 102: 535–542.

    PubMed  Google Scholar 

  22. Baggs, R. B., Miller, S. A.: Nutritional iron deficiency as a determinant of host resistance in the rat. Journal of Nutrition 1973, 103: 1554–1560.

    PubMed  Google Scholar 

  23. Hegenauer, J., Saltmann, P.: Iron susceptibility to infectious disease. Science 1975, 188: 1038–1040.

    PubMed  Google Scholar 

  24. Bullen, J. J., Rogers, H. J., Griffiths, E.: Bacterial iron metabolism in infection and immunity. In: Neilands, J. B. (ed.): Microbial iron metabolism. Academic Press, New York, 1974, p. 518–552.

    Google Scholar 

  25. Sword, C. P.: Mechanism of pathogenesis inListeria monocytogenes infection. Influence of iron. Journal of Bacteriology 1966, 92: 536–542.

    PubMed  Google Scholar 

  26. Jones, R. L., Peterson, C. M., Grady, R. W., Kumbaraci, T., Cerami, A.: Effects of iron chelators and iron overload on salmonella infection. Nature, 1977, 267: 63–64.

    Article  Google Scholar 

  27. Holbein, B. E.: Iron-controlled infection withNeisseria meningitidis in mice. Infection and Immunity 1980, 29: 886–891.

    PubMed  Google Scholar 

  28. Bullen, J. J.: The significance of iron infection. Reviews of Infectious Diseases 1981, 3: 1127–1138.

    PubMed  Google Scholar 

  29. Aisen, P.: Iron transport and storage proteins. Annual Review of Biochemistry 1980, 49: 357–393.

    Article  PubMed  Google Scholar 

  30. Masson, P. L., Heremans, J. F., Dive, C.: An iron-binding protein common to many external secretions. Clinica Chimica Acta 1966, 14: 735–739.

    Article  Google Scholar 

  31. Bullen, J. J., Armstrong, J. A.: The role of lactoferrin in the bactericidal function of polymorphonuclear leucocytes. Immunology 1979, 36: 781–791.

    PubMed  Google Scholar 

  32. Bullen, J. J., Cushnie, G. H., Rogers, H. J.: The abolition of the protective effect ofClostridium welchii type A antiserum by ferric. Immunology 1967, 12: 303–312.

    PubMed  Google Scholar 

  33. Bullen, J. J., Wilson, A. B., Cushnie, G. H., Rogers, H. J.: The abolition of the protective effect ofPasteurella septica antiserum by iron compounds. Immunology 1968, 14: 889–898.

    PubMed  Google Scholar 

  34. Griffiths, E.: Mechanism of action of specific antiserum onPasteurella septica. Selective inhibition of net macromolecular synthesis and its reversal by iron compounds. European Journal of Biochemistry 1971, 23: 69–76.

    Article  PubMed  Google Scholar 

  35. Trousseau, A.: Lectures on Clinical Medicine. New Sydenham Society, London, 1972, p. 96.

    Google Scholar 

  36. Barry, D. M. J., Reeve, A. W.: Increased incidence of gram-negative neonatal sepsis with intramuscular iron administration. Pediatrics 1977, 60: 908–912.

    PubMed  Google Scholar 

  37. Becroft, D. M. O., Dix, M. R., Farmer, K.: Intramuscular iron-dextran and susceptibility of neonates to bacterial infection. Archives of Disease in Childhood 1977, 52: 778–781.

    PubMed  Google Scholar 

  38. Barry, D. M. J., Reeve, A. W.: Iron and neonatal infection. The Hawkes Bay Experience. New Zealand Medical Journal 1976, 84: 287–290.

    Google Scholar 

  39. Farmer, K., Becroft, D. M. O.: Administration of parenteral iron to newborn infants. Archives of Disease in Childhood 1976, 51: 486–489.

    Google Scholar 

  40. McFarlane, H., Okubadejo, M., Reddy, S.: Transferrin andStaphylococcus aureus in kwashiorkor. Americal Journal of Clinical Pathology 1972, 57: 587–591.

    Google Scholar 

  41. McFarlane, H., Reddy, S., Adcock, K. J., Adeshina, H., Cooke, A. R., Akene, J.: Immunity, transferrin and survival in kwashiorkor. British Medical Journal 1970, iv: 268–270.

    Google Scholar 

  42. Murray, M. J., Murray, A. B., Murray, M. B., Murray, C. J.: The adverse effect of iron repletion on the course of certain infections. British Medical Journal 1978, ii: 1113–1115.

    Google Scholar 

  43. Murray, M. J., Murray, A., Murray, C. J.: The salutary effect of milk on amoebiasis and its reversal by iron. British Medical Journal 1980, i: 1351–1352.

    Google Scholar 

  44. Massawe, A. E. J., Muindi, J. M., Swai, G. B. R.: Infections in iron deficiency and other types of anaemia in the tropics. Lancet 1974, ii: 314–317.

    Article  Google Scholar 

  45. Byles, A. B., D'sa, A.: A case of empirical therapy in the management of anaemia in pregnancy in developing countries. East African Medical Journal 1975, 10: 555–563.

    Google Scholar 

  46. Fletcher, J., Goldstein, E.: The effect of parenteral iron preparations on experimental pyelonephritis. British Journal of Experimental Pathology 1970, 51: 280–285.

    PubMed  Google Scholar 

  47. Bornside, G. H., Bouis, P. J., Cohn, E.: Hemoglobin andEscherichia coli — a lethal intraperitoneal combination. Journal of Bacteriology 1968, 95: 1567–1571.

    PubMed  Google Scholar 

  48. Bullen, J. J., Leigh, L. C., Rogers, H. J.: The effect of iron compounds on the virulence ofEscherichia coli for guinea pigs. Immunology 1968, 15: 581–588.

    PubMed  Google Scholar 

  49. Bullen, J. J., Rogers, H. J., Griffiths, E.: Role of iron in bacterial infection. Current Topics in Microbiology and Immunology 1978, 80: 1–35.

    PubMed  Google Scholar 

  50. Davis, J. H., Yull, A. B.: A toxic factor in abdominal injury. II. The role of the red cell component. Journal of Trauma 1964, 4: 84–90.

    Google Scholar 

  51. Cuadra, M.: Salmonellosis complications in human bartonellosis. Texas Reports of Biology and Medicine 1956, 14: 97–113.

    Google Scholar 

  52. Barrett-Conner, E.: Bacterial infection and sickle cell anemia. Medicine 1971, 50: 97–112.

    PubMed  Google Scholar 

  53. Ward, P. A., Goldschmidt, P., Greene, N. D.: Suppressive effects of metal salts on leukocyte and fibroblasts function. Journal of the Reticuloendothelial Society 1975, 18: 313–321.

    PubMed  Google Scholar 

  54. Gladstone, G. P., Walton, E.: The effect of iron and haematin on the killing of staphylococci by rabbit polymorphs. British Journal of Experimental Pathology 1971, 152: 452–464.

    Google Scholar 

  55. Schultz, J., Rosenthal, S.: Iron. II. Inactivation of myeloperoxidase. Journal of Biological Chemistry 1959, 234: 2486–2490.

    PubMed  Google Scholar 

  56. Kaplan, S. S., Quie, P. G., Baford, R. E.: Effect of iron on leukocyte function: inactivation of H2O2 by iron. Infection and Immunology 1975, 12: 303–308.

    Google Scholar 

  57. Fisher, E. R., Fisher, B.: Hepatic damage by reticuloendothelial interference. Archives of Pathology 1963, 75: 191–195.

    PubMed  Google Scholar 

  58. Gabrielli, E. R., Holmgren, H.: Studies in the blockade of the reticuloendothelial system. Acta Pathologica et Microbiologica Scandinavica 1952, 31: 205–211.

    PubMed  Google Scholar 

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van Asbeck, B.S., Verhoef, J. Iron and host defence. Eur. J, Clin. Microbiol. 2, 6–10 (1983). https://doi.org/10.1007/BF02019915

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