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Comparative synergistic activity of netilmicin-piperacillin versus gentamicin-piperacillin

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Abstract

The synergistic action of the combination netilmicin-piperacillin in comparison to gentamicin-piperacillin was studied in 206 clinical isolates of staphylococci, enterococci,Enterobacteriaceae andPseudomonas aeruginosa by means of the checkerboard technique. Overall, netilmicin-piperacillin acted synergistically against 31 % and gentamicin-piperacillin against 14 % of the 206 strains. In particular, synergism was more frequently observed with netilmicin-piperacillin againstEscherichia coli, Citrobacter spp., indole-positiveProteus spp. andPseudomonas aeruginosa. Synergy was uncommon with either combination against enterococci,Staphylococcus epidermidis andSerratia spp. Only partial synergy or indifference was seen with both combinations againstKlebsiella spp. The interaction of netilmicin would appear to be superior to that of gentamicin in combination with piperacillin.

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Authors and Affiliations

  1. Institute of Medical Microbiology, Technical University, Ismaningerstr. 22, 8000, Munich 80, FRG

    K. Machka, W. Baierl & I. Braveny

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  1. K. Machka
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  2. W. Baierl
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  3. I. Braveny
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Machka, K., Baierl, W. & Braveny, I. Comparative synergistic activity of netilmicin-piperacillin versus gentamicin-piperacillin. Eur. J, Clin. Microbiol. 1, 238–242 (1982). https://doi.org/10.1007/BF02019715

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  • DOI: https://doi.org/10.1007/BF02019715

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