European Journal of Clinical Microbiology

, Volume 1, Issue 4, pp 233–237 | Cite as

Pharmacokinetic studies of amoxicillin, potassium clavulanate and their combination

  • G. Witkowski
  • H. Lode
  • G. Höffken
  • P. Koeppe
Original Articles

Abstract

Pharmacokinetic parameters after oral administration of 500 mg amoxicillin, 125 mg potassium clavulanate and 625 mg of their combination (augmentin) were determined in a randomized crossover study in ten healthy volunteers. The absolute bioavailability of amoxicillin (AUCoral/AUCi.v.) was 0.70±0.12. The mean maximum serum concentration of amoxicillin was 6.5±1.6 mg/l after administration alone and 6.5±1.4 mg/l after administration in combination. The respective values for potassium clavulanate were 3.4±1.4 mg/l and 2.8±1.1 mg/l. With both substances there was no significant difference between the pharmacokinetic parameters after administration alone and in combination. The AUC for amoxicillin was 19.5±5.4 h×mg/l after administration alone and 23.2±10.6 h×mg/l after administration in combination. The respective values for potassium clavulanate were 7.8±3.2 h×mg/l and 7.3±2.0 h×mg/l.

Keywords

Potassium Internal Medicine Healthy Volunteer Oral Administration Serum Concentration 

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Copyright information

© Vieweg Publishing 1982

Authors and Affiliations

  • G. Witkowski
    • 1
  • H. Lode
    • 2
  • G. Höffken
    • 2
  • P. Koeppe
    • 3
  1. 1.Institute of BiologyTechnische Universität BerlinBerlin 10FRG
  2. 2.Department of MedicineKlinikum Steglitz, Freie Universität BerlinBerlin 45FRG
  3. 3.Department of RadiologyKlinikum Steglitz, Freie Universität BerlinBerlin 45FRG

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