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Effect of alkaline glutaraldehyde on hepatitis B virus antigens

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Abstract

The potential of alkaline 2 % glutaraldehyde solutions, with and without surface active agents, to alter the antigenicity of hepatitis B virus (HBV) was analyzed and compared to the antigenic alternation capacities of 0.525 % sodium hypochlorite and 2.02 % formaldehyde solutions. After treatment of a hepatitis B surface antigen-positive plasma at room temperature for 10 min, there was a 51–67 % reduction in surface antigen level and a 90–94 % decrease in hepatitis B core antigenicity. Glutaraldehyde is proposed as an alternative to the more noxious hypochlorite and formaldehyde solutions for disinfection of HBV-contaminated articles.

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Authors and Affiliations

  1. Department of Virology and Epidemiology, Baylor College of Medicine, 77030, Houston, Texas, USA

    K. Adler-Storthz, G. R. Dreesman, F. B. Hollinger & J. L. Melnick

  2. Division of Epidemiology, Texas Department of Health, 78756, Austin, Texas, USA

    L. M. Sehulster

Authors
  1. K. Adler-Storthz
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  2. L. M. Sehulster
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  3. G. R. Dreesman
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  4. F. B. Hollinger
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  5. J. L. Melnick
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Adler-Storthz, K., Sehulster, L.M., Dreesman, G.R. et al. Effect of alkaline glutaraldehyde on hepatitis B virus antigens. Eur. J, Clin. Microbiol. 2, 316–320 (1983). https://doi.org/10.1007/BF02019460

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