Effect of nifedipine administration on pulse wave velocity (PWV) of chronic hemodialysis patients—2-year trial
Pulse wave velocity (PWV) is known to reflect the stiffness of the aorta [2,7], one of the major features of atherosclerosis. To clarify the severity and progression mechanism of atherosclerosis in hemodialysis patients and the preventive effect of nifedipine, PWV was annually measured for 2 years, and the change of PWV and contributory factors were analyzed. PWV in hemodialysis patients was faster than in age-matched normal controls. PWV was correlated with the duration of hemodialysis. ΔPWV, which is obtained from the difference in PWV over 1 year, was positively correlated with age, high blood pressure, and serum cholesterol levels and was negatively correlated with HDL levels. The Ca×Pi value was also positively correlated with ΔPWV. Nifedipine was administered to 47 patients for 2 years, and the change of PWV was compared with age-matched control hemodialysis patients. The PWV of the control group was gradually increased by 10%. The PWV of the group given nifedipine decreased by 2%. These results suggested that administration of nifedipine may prevent the progression of PWV in hemodialysis patients and may decrease the progression of atherosclerosis.
Key Wordspulse wave velocity nifedipine atherosclerosis hemodialysis
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- 2.Hasegawa G. Basic studies on pulse wave velocity of human aorta.Jikei Med J 1970;85:742–760.Google Scholar
- 4.Fleckenstein A, Frey M, Witzleben H. Vascular calcium overload—a pathogenic factor in atherosclerosis and its neutralization by Ca antagonists. In: Kaltenbach M, Neufeldt HN, eds.5th International Adalat Symposium. Amsterdam: Excerpta Medica, 1984:36–52.Google Scholar
- 6.Saito Y, Fujiyama Y, Shirai K, Yoshida S. Effect of nifedipine on lipid metabolism in smooth muscle cells. In: Lichtlen PR, ed.6th International Adalat Symposium. Amsterdam: Excerpta Medica, 1986:479–483.Google Scholar
- 7.Wezler K. Die Anwendung der phyrikalischen Methoden der schagvolunen bestimmung.Verh Dtrch Ges Kreisl 1940;15:18–28.Google Scholar