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Effects of nifedipine on cardiac function in patients with coronary artery disease evaluated with ambulatory radionuclide monitoring

  • Nifedipine, Cardioprotection, and Ischemic Heart Disease
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Summary

The effects of nifedipine on left ventricular function were evaluated in 17 patients with coronary artery disease with an ambulatory radionuclide detector (VEST). Hemodynamic data were recorded continuously at rest and during upringht bicycle ergometer exercise before and 30 minutes after 10 mg of oral nifedipine administration. The heart rate increased and the resting systolic blood pressure decreased significantly with nifedipine. The end-diastolic and end-systolic volumes during exercise were significantly reduced and EF increased during exercise after nifedipine administration. These salutary hemodynamic responses of nifedipine appear to be beneficial for patients with effort angina pectoris.

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References

  1. Imai S. Effects of nifedipine on heart and coronary circulation. In Hashimoto K, Kimura E, Kobayashi T, eds.Newtherapy of ischemic heart disease. Tokyo: University of Tokyo Press, 1975:23–30.

    Google Scholar 

  2. Guazzi M, Olivari MT, Polese A et al. Nifedipine, a new antihypertensive with rapid action.Clin Pharmacol Ther 1977;22:528–532.

    PubMed  Google Scholar 

  3. Atterhög JH, Ekelund LG, Melin AL. Effect of nifedipine on exercise tolerance in patients with angina pectoris.Eur J Clin Pharmacol 1975;8:125–130.

    PubMed  Google Scholar 

  4. Heupler FA, Proudfit WL. Nifedipine therapy for refractory coronary arterial spasm.Am J Cardiol 1979;44:798–803.

    Article  PubMed  Google Scholar 

  5. Moskowitz RM, Piccini PA, Nacarelli GV, et al. Nifedipine therapy for stable angina pectoris.Am J Cardiol 1979;44:811–816.

    PubMed  Google Scholar 

  6. Emanuelsson H, Holmberg S. Mechanisms of angina relief after nifedipine: A hemodynamic and myocardial metabolic study.Circulation 1983;68:124–130.

    PubMed  Google Scholar 

  7. Majid PA, DeJong, J. Acute hemodynamic effects of nifedipine in patients with ischemic heart disease.Circulation 1982;65:1114–1118.

    PubMed  Google Scholar 

  8. Specchia G, Servi S, Falcone C, et al. Effects of nifedipine on coronary hemodynamic findings during exercise in patients with stable exertional angina.Circulation 1983;68:1035–1043.

    PubMed  Google Scholar 

  9. Kambara H, Nohara R, Suzuki Y, et al. Effects of nitroglycerin and nifedipine on myocardial blood flow during ergometer exercise as assessed by13N ammonia positron computed tomography. In: Lichtlen PR, ed.New therapy of ischemic heart disease and hypertension. 6th Int Adalat Symp in Geneva. Amsterdam: Excerpta Medica, 1985:148–157.

    Google Scholar 

  10. Tamaki N, Yasuda T, Moore RH, et al. Continuous monitoring of left ventricular function by an ambulatory radionuclide detector in patients with coronary artery disease.J Am Coll Cardiol 1988;12:669–679.

    PubMed  Google Scholar 

  11. Bacharach SL, Green MV, Borer JS, et al. ECG gated scintillation probe measurement of left ventricular function.J Nucl Med 1977;18:1176–1183.

    PubMed  Google Scholar 

  12. Strashun A, Horowitz SF, Goldsmith SJ, et al. Noninvasive detection of left ventricular dysfunction with a portable gated scintillation probe device.Am J Cardiol 1981;47:610–617.

    Article  PubMed  Google Scholar 

  13. Berger HJ, Davies RA, Batsford WP, et al. Beat-to-beat left ventricular performance assessed from the equilibrium cardiac blood pool using a computerized nuclear probe.Circulation 1981;63:133–142.

    PubMed  Google Scholar 

  14. Strauss HW, Lazewatsky J, Moore RH, et al. The VEST: A device for the continuous monitoring of cardiac function in ambulatory patients (abstract).Circulation 1979;59(Suppl II): II246.

    Google Scholar 

  15. Wilson, RA, Sullivan PJ, Moore RH, et al. An ambulatory ventricular function monitor: Validation and preliminary results.Am J Cardiol 1983;52:601–606.

    Article  PubMed  Google Scholar 

  16. Tamaki N, Gill JB, Moore RH, et al. Cardiac response to daily activities and exercise in normal subjects assessed by an ambulatory ventricular function monitor.Am J Cardiol 1987;59:1164–1169.

    Article  PubMed  Google Scholar 

  17. Herman MV, Elliott WC, Gorlin R. An electroradiographic, anatomic and metabolic study of zonal myocardial ischemia in coronary artery disease.Circulation 1967;35:834–840.

    PubMed  Google Scholar 

  18. Upton MT, Rerych SK, Newman GE, et al. Detecting abnormalities in left ventricular function during exercise before angina and ST-segment depression.Circulation 1980;62:341–349.

    PubMed  Google Scholar 

  19. O'Hara HJ, Jones RI, Lahiri A, et al. Changes in left ventricular function during exercise and their relation to ST segment changes in patients with angina.Br Heart J 1986;55:148–154.

    PubMed  Google Scholar 

  20. Nelson GIC, Silke B, Ahuja RC, et al. Hemodynamic effects of nifedipine during upright exercise in stable angina pectoris and either normal or severely impaired left ventricular function.Am J Cardiol 1984;53:451–455.

    Article  PubMed  Google Scholar 

  21. Green MV, Brody WR, Douglas MA, et al. Ejection fraction by count rate from gated images.J Nucl Med 1978;19:880–883.

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Internal Medicine, Kyoto University, Kyoto, Japan

    Hirofumi Kambara MD, Tetsuo Fudo, Ryuji Nohara & Chuuichi Kawai

  2. Department of Nuclear Medicine, Kyoto University, Kyoto, Japan

    I. H. Mohiuddin, Nagara Tamaki, Masataka Hayashi & Junji Konishi

Authors
  1. Hirofumi Kambara MD
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  2. I. H. Mohiuddin
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  3. Nagara Tamaki
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  4. Tetsuo Fudo
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  5. Masataka Hayashi
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  6. Ryuji Nohara
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  7. Junji Konishi
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  8. Chuuichi Kawai
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Kambara, H., Mohiuddin, I.H., Tamaki, N. et al. Effects of nifedipine on cardiac function in patients with coronary artery disease evaluated with ambulatory radionuclide monitoring. Cardiovasc Drug Ther 4 (Suppl 5), 919–922 (1990). https://doi.org/10.1007/BF02018293

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  • DOI: https://doi.org/10.1007/BF02018293

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