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European Journal of Clinical Microbiology

, Volume 6, Issue 2, pp 198–200 | Cite as

Amikacin-containing regimens for treatment of nocardiosis in immunocompromized patients

  • F. W. Goldstein
  • B. Hautefort
  • J. F. Acar
Notes

Abstract

Eight patients with disseminated infections due to multi-resistantNocardia asteroideswere administered amikacin in combination with other effective antibiotics for a duration of 2 to 12 months. Seven patients were considered cured at follow-up after two years.

Keywords

Internal Medicine Amikacin Immunocompromized Patient Nocardiosis Effective Antibiotic 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Palmer, D. L., Harvey, R. L., Wheeler, J. K.: Diagnostic and therapeutic considerations inNocardia asteroides infection. Medicine 1974, 5: 391–401.Google Scholar
  2. 2.
    Simpson, G. L., Stinson, E. B., Egger, M. J., Remington, J. S.: Nocardial infections in the immunocompromized host: a detailed study in a defined population. Reviews of Infectious Diseases 1981, 3: 492–507.PubMedGoogle Scholar
  3. 3.
    Geiseler, P. J., Andersen, B. R.: Results of therapy in systemic nocardiosis. American Journal of the Medical Sciences 1979, 278: 188–194.PubMedGoogle Scholar
  4. 4.
    Smego, R. A., Moeller, M. B., Gallis, H. A.: Trimethoprim-sulfamethoxazole therapy for nocardia infections. Archives of Internal Medicine 1983, 143: 711–718.PubMedGoogle Scholar
  5. 5.
    Dalovisio, J. R., Pankey, G. A.: In vitro susceptibility ofNocardia asteroides to amikacin. Antimicrobial Agents and Chemotherapy 1978, 13: 128–129.PubMedGoogle Scholar
  6. 6.
    Gutmann, L., Goldstein, F. W., Kitzis, M.-D., Hautefort, B., Darmon, C., Acar, J. F.: Susceptibility ofNocardia asteroides to 46 antibiotics including 22 beta-lactams. Antimicrobial Agents and Chemotherapy 1983, 2: 248–251.Google Scholar
  7. 7.
    Kitzis, M.-D., Gutmann, L., Acar, J. F.: In vitro susceptibility ofNocardia asteroides, to 21 beta-lactam antibiotics, in combination with three beta-lactamase inhibitors, and its relationship to the beta-lactamase content. Journal of Antimicrobial Chemotherapy 1985, 15: 23–30.PubMedGoogle Scholar
  8. 8.
    Gombert, M. E.: Susceptibility ofNocardia asteroides to various antibiotics including newer beta-lactams trimethoprim-sulfamethoxazole, amikacin and N-formimidoyl thienamycin. Antimicrobial Agents and Chemotherapy 1982, 21: 1011–1012.PubMedGoogle Scholar
  9. 9.
    Yogev, R., Greenslade, P., Firlit, C. F., Lewy, P.: Successful treatment ofNocardia asteroides infection with amikacin. Journal of Pediatrics 1980, 96: 771–773.PubMedGoogle Scholar
  10. 10.
    Zaegel, R., Gaudouen, Y., Goldstein, F. W., Deloux, G., Blamoutier, J.: Nouvelle association thérapeutique utilisée avec succès dans un cas de nocardiose. La Presse Médicale 1983, 12: 643–644.Google Scholar
  11. 11.
    Meier, B., Metzger, U., Muller, F., Siegenthaler, W., Lüthy, R.: Successful treatment of a pancreaticNocardia asteroides abscess with amikacin and surgical drainage. Antimicrobial Agents and Chemotherapy 1986, 29: 150–151.PubMedGoogle Scholar
  12. 12.
    Byrne, E., Brophy, B. P., Perrett, L. V.: Nocardia cerebral abscess: new concepts in diagnosis, management, and prognosis. Journal of Neurology, Neurosurgery and Psychiatry 1979, 42: 1038–1045.Google Scholar

Copyright information

© Friedr. Vieweg & Sohn Verlagsgesellschaft mbH 1987

Authors and Affiliations

  • F. W. Goldstein
    • 1
  • B. Hautefort
    • 2
  • J. F. Acar
    • 1
  1. 1.Laboratoire de Microbiologie MédicaleHÔpital Saint-JosephParis Cedex 14France
  2. 2.Laboratoire de Microbiologie MédicaleHÔpital Joseph ImbertArlesFrance

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