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European Journal of Clinical Microbiology

, Volume 6, Issue 2, pp 173–178 | Cite as

Comparative in vitro activity of A-56268 (TE-031) against gram-positive and gram-negative bacteria andChlamydia trachomatis

  • C. Benson
  • J. Segreti
  • H. Kessler
  • D. Mines
  • L. Goodman
  • R. Kaplan
  • G. Trenholme
New Antimicrobial Agents

Abstract

The in vitro activity of A-56268 (TE-031) was determined and compared with that of 13 antibiotics against 401 gram-positive and gram-negative bacteria and 11 strains ofChlamydia trachomatis.A-56268 was very active against methicillin-susceptibleStaphylococcus aureusandNeisseria gonorrhoeae,and was among the most active of the agents tested againstListeria monocytogenes,streptococci andChlamydia trachomatis.It was moderately active againstHaemophilusspp.,Vibriospp.,Campylobacter jejuniandCampylobacter fetussubsp.fetus.It was inactive against enterococci, methicillin-resistantStaphylococcus aureus,Staphylococcus epidermidis, Campylobacter coli, Salmonellaspp.,Shigellaspp. andYersinia enterocolitica.A-56268 was not consistently bactericidal or more active than erythromycin for any organism exceptChlamydia trachomatis.

Keywords

Internal Medicine Erythromycin ofChlamydia Trachomatis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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    Thornsberry, C., McDougal, L. K.: Successful use of broth microdilution in susceptibility tests for methicillin-resistant (heteroresistant) staphylococci. Journal of Clinical Microbiology 1983, 18: 1084–1091.PubMedGoogle Scholar
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    National Committee for Clinical Laboratory Standards: Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. Volume 5. Villanova, PA, 1986, p. 579–616.Google Scholar
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    Benson, C. A., Walton, F. E., Trenholme, G. M.: Antibacterial activity of Ro 17-2301 and other antimicrobial agents against cefotaxime-resistant aerobic gram-negative bacilli. Antimicrobial Agents and Chemotherapy 1986, 29: 155–157.PubMedGoogle Scholar
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    Segreti, J., Kessler, H. A., Kapell, K. S., Trenholme, G. M.: In vitro activity of A-56268 (TE-031) and four other antimicrobial agents againstChlamydia trachomatis. Antimicrobial Agents and Chemotherapy 1987, 31: 100–101.PubMedGoogle Scholar

Copyright information

© Friedr. Vieweg & Sohn Verlagsgesellschaft mbH 1987

Authors and Affiliations

  • C. Benson
    • 1
  • J. Segreti
    • 1
  • H. Kessler
    • 1
  • D. Mines
    • 1
  • L. Goodman
    • 1
  • R. Kaplan
    • 1
  • G. Trenholme
    • 1
  1. 1.Section of Infectious Disease, Department of MedicineRush-Presbyterian-St. Luke's Medical CenterChicagoUSA

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