Comparative in vitro activity of A-56268 (TE-031) against gram-positive and gram-negative bacteria andChlamydia trachomatis
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The in vitro activity of A-56268 (TE-031) was determined and compared with that of 13 antibiotics against 401 gram-positive and gram-negative bacteria and 11 strains ofChlamydia trachomatis.A-56268 was very active against methicillin-susceptibleStaphylococcus aureusandNeisseria gonorrhoeae,and was among the most active of the agents tested againstListeria monocytogenes,streptococci andChlamydia trachomatis.It was moderately active againstHaemophilusspp.,Vibriospp.,Campylobacter jejuniandCampylobacter fetussubsp.fetus.It was inactive against enterococci, methicillin-resistantStaphylococcus aureus,Staphylococcus epidermidis, Campylobacter coli, Salmonellaspp.,Shigellaspp. andYersinia enterocolitica.A-56268 was not consistently bactericidal or more active than erythromycin for any organism exceptChlamydia trachomatis.
KeywordsInternal Medicine Erythromycin ofChlamydia Trachomatis
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