European Journal of Clinical Microbiology

, Volume 5, Issue 3, pp 297–302 | Cite as

Serum bactericidal activity of two newer quinolones againstSalmonella typhi compared with standard therapeutic regimens

  • M. Trautmann
  • B. Krause
  • D. Birnbaum
  • J. Wagner
  • V. Lenk


The bactericidal activity of two newer quinolones, ciprofloxacin and ofloxacin, against eight strains ofSalmonella typhiwas examined by the serum dilution test and studies of bacterial killing kinetics in human serum, and compared to standard regimens. Bactericidal titers for ciprofloxacin ranged from 1∶388 to 1∶119 two hours and from 1∶119 to 1∶57 six hours after volunteers received an oral dose of 500 mg. The respective titers obtained after a 200 mg oral dose of ofloxacin were somewhat lower, but still exceeded 1∶16 in all instances. Studies of bacterial killing kinetics demonstrated a rapid bactericidal action of both drugs against all strains tested. Compared to the classical anti-typhoid agents chloramphenicol, cotrimoxazole and amoxicillin, the new quinolones showed both markedly higher bactericidal titers and more rapid killing ofSalmonella typhiin human serum.


Bactericidal Activity Oral Dose Human Serum Chloramphenicol Amoxicillin 
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Copyright information

© Friedr, Vieweg & Sohn Verlagsgesellschaft mbH 1986

Authors and Affiliations

  • M. Trautmann
    • 1
  • B. Krause
    • 1
  • D. Birnbaum
    • 1
  • J. Wagner
    • 2
  • V. Lenk
    • 2
  1. 1.Division of Infectious Diseases, Department of Internal Medicine, Klinikum CharlottenburgFreie Universität BerlinBerlin 19FRG
  2. 2.Institute of Medical MicrobiologyFreie Universität BerlinBerlin 45FRG

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