Advertisement

European Journal of Clinical Microbiology

, Volume 5, Issue 3, pp 297–302 | Cite as

Serum bactericidal activity of two newer quinolones againstSalmonella typhi compared with standard therapeutic regimens

  • M. Trautmann
  • B. Krause
  • D. Birnbaum
  • J. Wagner
  • V. Lenk
Articles

Abstract

The bactericidal activity of two newer quinolones, ciprofloxacin and ofloxacin, against eight strains ofSalmonella typhiwas examined by the serum dilution test and studies of bacterial killing kinetics in human serum, and compared to standard regimens. Bactericidal titers for ciprofloxacin ranged from 1∶388 to 1∶119 two hours and from 1∶119 to 1∶57 six hours after volunteers received an oral dose of 500 mg. The respective titers obtained after a 200 mg oral dose of ofloxacin were somewhat lower, but still exceeded 1∶16 in all instances. Studies of bacterial killing kinetics demonstrated a rapid bactericidal action of both drugs against all strains tested. Compared to the classical anti-typhoid agents chloramphenicol, cotrimoxazole and amoxicillin, the new quinolones showed both markedly higher bactericidal titers and more rapid killing ofSalmonella typhiin human serum.

Keywords

Bactericidal Activity Oral Dose Human Serum Chloramphenicol Amoxicillin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Herzog, C., Geddes, A. M.: Chloramphenicol in the treatment of typhoid fever. Transactions of the Royal Society of Tropical Medicine and Hygiene 1982, 76: 848–849.CrossRefPubMedGoogle Scholar
  2. 2.
    Mukhtar, E. D., Mekki, M. O.: Trimethoprim-sulphamethoxazole in the treatment of enteric fever in the Sudan. Transactions of the Royal Society of Tropical Medicine and Hygiene 1981, 75: 771–773.CrossRefPubMedGoogle Scholar
  3. 3.
    Snyder, M. J., Perroni, J., Gonzalez, O., Palomino, C., Gonzalez, C., Music, St., DuPont, H. L., Hornick, R. B., Woodward, T. E.: Trimethoprim-sulfamethoxazole in the treatment of typhoid and paratyphoid fevers. Journal of Infectious Diseases 1973, 128, Supplement: S734-S737.Google Scholar
  4. 4.
    Kamat, S. A.: Evaluation of therapeutic efficacy of trimethoprim-sulphamethoxazole and chloramphenicol in enteric fever. British Medical Journal 1970, 3: 320–322.PubMedGoogle Scholar
  5. 5.
    Scragg, J. N., Rubidge, C. J.: Trimethoprim and sulphamethoxazole in typhoid fever in children. British Medical Journal 1971, 3: 738–741.PubMedGoogle Scholar
  6. 6.
    Böttiger, L. E.: Epidemiology and aetiology of aplastic anaemia. Haematologie und Bluttransfusion 1979, 24: 27–36.Google Scholar
  7. 7.
    Anderson, E. S.: The problem and implications of chloramphenicol resistance in the typhoid bacillus. Journal of Hygiene 1975, 74: 289–299.PubMedGoogle Scholar
  8. 8.
    Tanphaichitra, D., Siristonupum, Y., Tanphaichitra, V., Sukathat, O.: Typhoid fever: report of 511 cases — complications, antibiogram and clinical trial with mecillinam/ampicillin combination. In: Current Chemotherapy of Infectious Diseases. American Society for Microbiology, Washington D.C., 1980, p. 926–927.Google Scholar
  9. 9.
    Rangnekar, V. M., Banker, D. D., Jhala, H. I.: Plasmidmediated multidrug resistance inSalmonella typhi. Lancet 1981, ii: 364.CrossRefGoogle Scholar
  10. 10.
    Tanphaichitra, D., Srimuang, S., Chiaprasittigul, P., Mendary, P., Christensen, O. E.: The combination of pivmecillinam and pivampicillin in the treatment of enteric fever. Infection 1984, 12: 381–383.CrossRefPubMedGoogle Scholar
  11. 11.
    Herzog, C.: New trends in the chemotherapy of typhoid fever. Acta Tropica 1980, 37: 275–280.PubMedGoogle Scholar
  12. 12.
    Ball, A. P., Geddes, A. M.: Management of enteric fever with amdinocillin. American Journal of Medicine 1983, 75, Supplement: 130–133.CrossRefPubMedGoogle Scholar
  13. 13.
    Pillay, N., Adams, E. B., North-Coombes, D.: Comparative trial of amoxycillin and chloramphenicol in treatment of typhoid fever in adults. Lancet 1975, ii: 333–334.CrossRefGoogle Scholar
  14. 14.
    Tanphaichitra, D., Bussayanond, A., Christensen, O.: The combination of pivmecillinam and pivampicillin compared to co-trimoxazole in the treatment of enteric fever. Infection 1982, 10: 81–84.CrossRefPubMedGoogle Scholar
  15. 15.
    Goossens, H., de Mol, P., Coignau, H., Levy, J., Grados, O., Ghysels, G., Innocent, H., Butzler, J. P.: Comparative in vitro activities of aztreonam, ciprofloxacin, norfloxacin, ofloxacin, HR 810 (a new cephalosporin), RU 28965 (a new macrolide), and other agents against enteropathogens. Antimicrobial Agents and Chemotherapy 1985, 27: 388–392.PubMedGoogle Scholar
  16. 16.
    Sanford, J. P., Linh, N. N., Kutschet, E., Arnold, K., Could, K.: Oxolinic acid in the treatment of typhoid fever due to chloramphenicol-resistant strains ofSalmonella typhi. Antimicrobial Agents and Chemotherapy 1976, 9: 387–392.PubMedGoogle Scholar
  17. 17.
    Simon, C., Stille, W.: Antibiotikatherapie in Klinik und Praxis. Schattauer-Verlag, Stuttgart, 1985.Google Scholar
  18. 18.
    Stratton, Ch. W., Reller, L. B.: Serum dilution test for bactericidal activity. I. Selection of a physiologic diluent. Journal of Infectious Diseases 1977, 136: 187–195.PubMedGoogle Scholar
  19. 19.
    Schlichter, J. G., MacLean, H.: A method of determining the effective therapeutic level in the treatment of subacute bacterial endocarditis with penicillin. A preliminary report. American Heart Journal 1947, 34: 209–211.CrossRefGoogle Scholar
  20. 20.
    Klastersky, J., Daneau, D., Swings, G., Weerts, D.: Antibacterial activity in serum and urine as a therapeutic guide in bacterial infections. Journal of Infectious Diseases 1974, 129: 187–193.PubMedGoogle Scholar
  21. 21.
    Klastersky, J.: The bactericidal activity in serum and its prognostic clinical value. Infection 1983, 11, Supplement 2: S93-S96.CrossRefPubMedGoogle Scholar
  22. 22.
    Platt, R., Ehrlich, S. L., Afarian, J., O'Brien, T. F., Pennington, J. E., Kass, E. H.: Moxalactam therapy of infections caused by cephalothin-resistant bacteria: influence of serum inhibitory activity on clinical response and acquisition of antibiotic resistance during therapy. Antimicrobial Agents and Chemotherapy 1981, 20: 351–355.PubMedGoogle Scholar
  23. 23.
    Van Laethem, Y., Lagast, H., Klastersky, J.: Serum bactericidal activity of ceftazidime and cefoperazone alone or in combination with amikacin againstPseudomonas aeruginosa andKlebsiella pneumoniae. Antimicrobial Agents and Chemotherapy 1983, 23: 435–439.PubMedGoogle Scholar
  24. 24.
    Uwaydah, M., Nassar, N. T., Harakeh, H., Vartivarian, S., Talhouk, A., Kantarjian, H.: Treatment of typhoid fever with cefamandole. Antimicrobial Agents and Chemotherapy 1984, 26: 426–427.PubMedGoogle Scholar
  25. 25.
    Uwaydah, M.: Cefazolin in the treatment of acute enteric fever. Antimicrobial Agents and Chemotherapy 1976, 10: 52–56.PubMedGoogle Scholar
  26. 26.
    Hornick, R. B., Greisman, S. E., Woodward, T. E., DuPont, H. L., Dawkins, A. T., Snyder, M. J.: Typhoid fever: pathogenesis and immunological control. New England Journal of Medicine 1970, 283: 686–691, 739–746.PubMedGoogle Scholar
  27. 27.
    Mims, C. A.: The pathogenesis of infectious diseases. Academic Press, London, 1976.Google Scholar
  28. 28.
    McLeod, F., Manyan, D. R., Yunis, A. A.: The cellular transport of chloramphenicol and thiamphenicol. Journal of Laboratory and Clinical Medicine 1977, 90: 347–353.PubMedGoogle Scholar
  29. 29.
    Traub, W.: Intraphagocytic bactericidal activity of bacterial DNA gyrase inhibitors againstSerratia marcescens. Chemotherapy 1984, 30: 379–386.PubMedGoogle Scholar

Copyright information

© Friedr, Vieweg & Sohn Verlagsgesellschaft mbH 1986

Authors and Affiliations

  • M. Trautmann
    • 1
  • B. Krause
    • 1
  • D. Birnbaum
    • 1
  • J. Wagner
    • 2
  • V. Lenk
    • 2
  1. 1.Division of Infectious Diseases, Department of Internal Medicine, Klinikum CharlottenburgFreie Universität BerlinBerlin 19FRG
  2. 2.Institute of Medical MicrobiologyFreie Universität BerlinBerlin 45FRG

Personalised recommendations