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Parathyroid hormone as a stimulus to mast cell accumulation in bone

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Abstract

Low doses of parathyroid hormone were administered over a 30-day period to Sprague-Dawley weanlings rats. In 7 of 12 animals, mast cell hyperplasia occurred in the proximal tibial metaphyseal marrow, without an associated fall in serum phosphorus or rise in serum calcium. Further, no alteration occurred in body weight or skeletal ash weight relative to the control population. A third group, on a calcium-deficient diet containing adequate vitamin D, showed marked bone marrow mast cell hyperplasia in all animals.

Résumé

Des doses faibles d'hormone parathyroidienne sont administrées pendant 30 jours à des rats sevrés de l'espèce Sprague-Dawley. Chez 7 des 12 animaux utilisés, une hyperplasie des mastocytes est observée dans la moëlle tibiale métaphysaire proximale, sans chute associée du phosphore sérique ou élévation du calcium sérique. En outre, aucun changement de poids corporel ou du poids des cendres squelettiques n'est observé par rapport aux témoins. Un troisième groupe, soumis à une alimentation pauvre en calcium, mais contenant une quantité suffisante de vitamine D, présente une hyperplasie mastocytaire marquée au niveau de la moëlle osseuse de tous les animaux.

Zusammenfassung

Entwöhnte Sprague-Dawley-Ratten erhiclten während einer Periode von 30 Tagen niedrige Dosen von Parathyroidhormon. 7 von 12 Tieren zeigten eine Mastzell-Hyperplasie im proximalen Teil des Tibiametaphysenmarks, ohne gleichzeitige Erniedrigung des Serumphosphates oder Anstieg des Serumcalciums. Femer traten im Vergleich zur Kontrollgruppe keine Veränderungen im Körpergewicht oder im Gewicht des Aschenrückstandes des Skelets auf. Eine dritte Gruppe, die eine Calcium-arme, entsprechend mit Vitamin D angereicherte Nahrung erhielt, zeigte eine ausgeprägte Mastzell-Hyperplasie im Knochenmark aller Tiere.

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David Rockoff, S., Armstrong, J.D. Parathyroid hormone as a stimulus to mast cell accumulation in bone. Calc. Tis Res. 5, 49–55 (1970). https://doi.org/10.1007/BF02017533

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  • DOI: https://doi.org/10.1007/BF02017533

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