Calcified Tissue Research

, Volume 13, Issue 1, pp 169–172 | Cite as

Effect of salmon calcitonin onin vivo calcium absorption in rats

  • C. F. Cramer
Original Papers

Abstract

Young calcitonin-deficient rats were prepared by thyroparathyroidectomy, and some of these received replacement therapy of parathyroid hormone and/or thyroxine. Disappearance of45Ca from the intestinal tract by 4 hours and appearance of the radioactivity in the carcass at 4 hours were measured as indexes of absorption. Salmon calcitonin in physiological or pharmacological dosages failed to alter thein vivo net45Ca absorption in the rats which were deficient in calcitonin alone, or in calcitonin and thyroxine, or in calcitonin, thyroxine and parathyroid hormone. Restoration of parathyroid hormone enhanced45Ca absorption above that in parathyroid deficient rats.

Key words

Calcitonin Calcium Intestine Absorption Parathyroid 

Résumé

De jeunes rats déficients en calcitonine sont thyroparathyroidectomisés et certains de ces animaux subissent un traitement de substitution avec de la parathormone et/ou de la thyroxine. La disparition du45Ca du tractus intestinal et l'apparition de radioactivité dans la carcasse aprés 4 heures ont été mesurées comme index d'apsorption. De la calcitonine de saumon, à des doses physiologiques ou pharmacologiques, ne modifie pas l'absorptionin vivo du45Ca chez les rats déficients en calcitonine, ou en calcitonine et thyroxine, ou encore en calcitonine, thyroxine et parathormone. L'administration de parathormone augmente l'absorption en45Ca, observée chez les rats présentant une déficience de cette hormone.

Zusammenfassung

Junge Ratten mit Calcitonin-Mangel wurden thyroparathyreoidektomiert, und einige dieser Ratten erhielten Parathormon und/oder Thyroxin als Ersatz. Das Verschwinden des45Ca aus dem Darm und das Erscheinen der Radioaktivität im Skelet nach 4 Std wurden als Index der Absorption gemessen. Salm-Calcitonin in physiologischen oder pharmakologischen Mengen rief keine Veränderung der Absorption von45Cain vivo in den Ratten hervor, welche nur an Calcitonin-Mangel litten. Auch die Calcitonin- und Thyroxinmangelratten und die Calcitonin-, Thyroxin- und Parathormonmagelratten zeigten keine Veräderung. Ratten, welche wieder Parathormon erhielten, zeigten noch höhere45Ca-Absorption als Parathormonmangelratten.

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Copyright information

© Springer-Verlag 1973

Authors and Affiliations

  • C. F. Cramer
    • 1
  1. 1.Department of PhysiologyUniversity of British ColumbiaVancouverCanada

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