Abstract
Radioactive calcium was orally applied to female albino rats fed for 6 months on a diet supplemented with the calcium salt of oxytetracycline (0.3 g/100 g dry food) and calcium metabolism was investigated. The results show that the percentage absorption of radioactive calcium was approximately equal in the experimental group which received oxytetracycline and in the control group which ate the same food without the antibiotic. However, the group which received the oxytetracycline supplemented diet consumed more food, so that with the same percentage absorption and elimination more calcium was retained in the body. This was reflected in higher stable calcium values in the carcass and in higher femur weights, but the difference between two groups was not significant.
Abstract
Du calcium radioactif est administréper os à des rattes albinos, soumises pendant 6 mois à une alimentation contenant du sel calcique d'oxytétracycline (0.3 g/100 g de régime sec) et le métabolisme du calcium a été étudié. Les résultats indiquent que le porcentage d'absorption de calcium radioactif est environ similaire dans le groupe expérimental recevant l'oxytétracycline et le groupe témoin recevant la même alimentation sans tétracycline. Cependant le groupe, recevant l'antibiotique, consomme plus de nourriture, de telle sorte qu'avec le même pourcentage d'absorption et d'élimination, plus de calcium est retenu. Ce fait se traduit par des valeurs plus élevées de calcium stabilisé au niveau des carcasses et des poids plus élevés du fémur, mais la différence entre les deux groupes n'est pas significative.
Zusammenfassung
Weibliche Albinoratten erhielten radioaktives Calcium per os, nachdem sie 6 Monate lang mit einer Diät gefüttert worden waren, die das Calciumsalz von Oxytetracyclin (0,3 g/100g Trockennahrung) zusätzlich enthielt. Dann wurde der Calciumstoffwechsel untersucht. Die Resultate zeigten, daß die prozentuale Absorption von radioaktivem Calcium in der experimentellen Gruppe, welche Oxytetracyclin erhielt, und in der Kontrollgruppe, welche die gleiche Nahrung ohne das Antibioticum erhielt, etwa gleich war. Die Gruppe mit der Oxytetracyclindiät nahm jedoch mehr Futter zu sich, so daß bei gleichem Prozentsatz von Absorption und Ausscheidung mehr Calcium im Körper zurückgehalten wurde. Dies zeigte sich in höheren Konzentrationen des nicht radioaktiven Calciums im Skelet und in höherem Femurgewicht, aber der Unterschied zwischen den zwei Gruppen war nicht signifikant.
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Gruden, N. Calcium metabolism in the rat in relation to prolonged administration of tetracyclines. Calc. Tis Res. 13, 41–46 (1973). https://doi.org/10.1007/BF02015394
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DOI: https://doi.org/10.1007/BF02015394