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Penicillin concentrations in blood and spinal fluid after a single intramuscular injection of penicillin G benzathine

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Abstract

The concentration of penicillin in cerebrospinal fluid and blood was measured after a single i.m. injection of 1.44 g penicillin G benzathine in 18 individuals (4 with neurosyphilis and 14 with neurological symptoms but not syphilis). Only one person had a treponemicidal concentration in the cerebrospinal fluid.

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Authors and Affiliations

  1. Statens Seruminstitut, Department of Clinical Microbiology at Hvidovre Hospital, Hvidovre Hospital, University of Copenhagen, Kettegaard Alle 30, DK-2650, Hvidovre, Denmark

    P. B. Nielsen & F. Espersen

  2. Department of Dermatovenereology, Hvidovre Hospital, University of Copenhagen, Kettegaard Alle 30, DK-2650, Hvidovre, Denmark

    G. Frentz

  3. Department of Rheumatology, Hvidovre Hospital, University of Copenhagen, Kettegaard Alle 30, DK-2650, Hvidovre, Denmark

    A. Czartoryski

  4. Department of Neurology, Hvidovre Hospital, University of Copenhagen, Kettegaard Alle 30, DK-2650, Hvidovre, Denmark

    H. Aastrup

Authors
  1. G. Frentz
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  2. P. B. Nielsen
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  3. F. Espersen
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  4. A. Czartoryski
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  5. H. Aastrup
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Frentz, G., Nielsen, P.B., Espersen, F. et al. Penicillin concentrations in blood and spinal fluid after a single intramuscular injection of penicillin G benzathine. Eur. J, Clin. Microbiol. 3, 147–149 (1984). https://doi.org/10.1007/BF02014334

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  • DOI: https://doi.org/10.1007/BF02014334

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