Skip to main content
SpringerLink
Log in

Activity of cephalosporins against methicillin-resistant coagulasenegative staphylococci

  • Short Reports
  • Published:
European Journal of Clinical Microbiology Aims and scope Submit manuscript

Abstract

Using a dilution method (37 °C, 42 h), six of ten methicillin-resistant strains of coagulase-negative Staphylococci were found to be resistant to cephalothin. Of 20 variations in the method for detection of resistance to methicillin and cephalothin, broth dilution tests at 30 °C for 42 h were the most sensitive. Differences are explained by low percentages of cephalothin-resistant clones in methicillin-resistant strains.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Hewitt, J. H., Parker, M. T.: Sensitivity of penicillinaseforming strains ofStaphylococcus aureus and of their penicillinase-negative variants to cephaloridine, cephalothin, methicillin and benzylpenicillin. Journal of Clinical Pathology 1968, 21: 75–84.

    PubMed  Google Scholar 

  2. Kayser, F. H.: Die Resistenz methicillin-resistenter Staphylokokken gegenüber neuen Cephalosporin-Antibiotika. Infection 1980, 8: 165–169.

    Article  PubMed  Google Scholar 

  3. Richmond, A. S., Simberkoff, M. S., Schaeffer, S., Rahal, J. J.: Resistance ofStaphylococcus aureus to semisynthetic penicillins and cephalothin. Journal of Infectious Diseases 1977, 135: 108–112.

    PubMed  Google Scholar 

  4. Laverdiere, M., Peterson, P. K., Verhoef, J., Williams, D. N., Sabath, L. D.: In vitro activity of cephalosporins against methicillin-resistant, coagulase-negative staphylococci. Journal of Infectious Diseases 1978, 137: 245–250.

    PubMed  Google Scholar 

  5. Churcher, G. M.: A screening test for the detection of methicillin-resistant staphylococci. Journal of Clinical Pathology 1968, 21: 213–217.

    PubMed  Google Scholar 

  6. Bulger, R. H.: A methicillin-resistant strain ofStaphylococcus aureus; clinical and laboratory experience. Annals of Internal Medicine 1967, 67: 81–89.

    PubMed  Google Scholar 

  7. Sawai, T., Takahashi, I., Yamagishi, S.: lodometric assay method for beta-lactamase with various beta-lactam antibiotics as substrates. Antimicrobial Agents and Chemotherapy 1978, 13: 910–913.

    PubMed  Google Scholar 

  8. Kloos, W. E., Schleifer, K. H.: Simplified scheme for routine identification of humanStaphylococcus species. Journal of Clinical Microbiology 1975, 1: 82–88.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Medical Microbiology, University Hospital and State University Leiden, Rijnsburgerweg 10, 2333, AA Leiden, The Netherlands

    R. P. Mouton, A. S. Lampe, D. B. van Maanen & T. J. K. van der Reijden

Authors
  1. R. P. Mouton
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. S. Lampe
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. D. B. van Maanen
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. T. J. K. van der Reijden
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mouton, R.P., Lampe, A.S., van Maanen, D.B. et al. Activity of cephalosporins against methicillin-resistant coagulasenegative staphylococci. Eur. J, Clin. Microbiol. 3, 144–146 (1984). https://doi.org/10.1007/BF02014333

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02014333

Keywords

Search

Navigation