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, Volume 42, Issue 1–2, pp 71–73 | Cite as

Superoxide dismutase inhibits interleukin-1-induced degradation of human cartilage

  • Kanji Fukuda
  • Hidekazu Dan
  • Masakatsu Saitoh
  • Masafumi Takayama
  • Seisuke Tanaka
Bone and Cartilage

Abstract

Interleukin-1 (IL-1) is a key mediator in the pathogenesis of cartilage destruction in arthritis-related disorders. Human recombinant superoxide dismutase (SOD) blocked IL-1-mediated cartilage destruction but had no effect on IL-1-mediated changes in glycosaminoglycan and prostaglandin E2 synthesis. These data suggest that superoxide anions may be one factor of IL-1-mediated cartilage destruction.

Key words

Arthritis Superoxide anion 

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Copyright information

© Birkhäuser Verlag 1994

Authors and Affiliations

  • Kanji Fukuda
    • 1
  • Hidekazu Dan
    • 1
  • Masakatsu Saitoh
    • 1
  • Masafumi Takayama
    • 1
  • Seisuke Tanaka
    • 1
  1. 1.Department of Orthopaedic SurgeryKinki University School of MedicineOsaka-sayama, OsakaJapan

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