Superoxide dismutase inhibits interleukin-1-induced degradation of human cartilage
- 33 Downloads
Interleukin-1 (IL-1) is a key mediator in the pathogenesis of cartilage destruction in arthritis-related disorders. Human recombinant superoxide dismutase (SOD) blocked IL-1-mediated cartilage destruction but had no effect on IL-1-mediated changes in glycosaminoglycan and prostaglandin E2 synthesis. These data suggest that superoxide anions may be one factor of IL-1-mediated cartilage destruction.
Key wordsArthritis Superoxide anion
Unable to display preview. Download preview PDF.
- V. C. Hascall, T. I. Morales, G. K. Hascall, C. J. Handley and D. J. McQuillan,Biosynthesis and turnover of proteoglycans in organ cultures of bovine articular cartilage., J. Rheumatol.11, (Suppl.). 45–52 (1983).Google Scholar
- R. W. Frandale, C. A. Sayers and A. J. Barrett,A direct spectrophotometric microssay for sulfated glycosaminoglycans in cartilage cultures. Connective Tissue Res.9, 247–248 (1982).Google Scholar
- Y. Iwasaki, Y. Saegusa, Y. Matsubara and K. Hirohata,Increased superoxide anion release from chondrocytes in response to interleukin I and interferons J. Jpn. Orthop. Assoc.64, 976–982 (1990).Google Scholar
- H. Burkhardt, M. Schwinger, H. Menninger, H. W. Macartney and H. Tschesche,Oxygen radicals as effecters of cartilage destruction. Arth. Rheum.29, 379–386 (1986).Google Scholar