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, Volume 42, Issue 1–2, pp 29–33 | Cite as

Protective effects of papaverine salicylate in mouse ear dermatitis and PAF-induced rat paw oedema

  • E. de Bernardis
  • G. Leonardi
  • A. Caruso
  • V. M. C. Cutuli
  • M. Amico-Roxas


Papaverine salicylate (MR-800) has been tested as a topical antiinflammatory agent in several models of skin inflammation in rodents, such as mouse ear dermatitis induced by croton oil, cantharidin or zymosan, and rat paw oedema induced by PAF. MR-800 exerted a dose-dependent inhibitory activity in all assays, when equimolar doses of sodium salicylate or papaverine were less effective, suggesting the existence of a favourable synergism between salicylate and papaverine.

Key words

Papaverine salicylate Croton oil Cantharidin Zymosan PAF 


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Copyright information

© Birkhäuser Verlag 1994

Authors and Affiliations

  • E. de Bernardis
    • 1
  • G. Leonardi
    • 1
  • A. Caruso
    • 1
  • V. M. C. Cutuli
    • 1
  • M. Amico-Roxas
    • 1
  1. 1.Institute of PharmacologyUniversity of Catania Medical SchoolCataniaItaly

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