Beta-lactamase hydrolysis and inhibition studies of the new 1-carbacephem LY163892
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A novel 1-carbacephem, LY163892, was determined to be more stable to plasmid-mediated beta-lactamases than cefaclor. Chromosomal-mediated Type Ia and IVc enzymes destroyed LY163892 at rates ranging from 16 to 93% that of nitrocefin. LY163892 showed minimal ability to inhibit beta-lactamases other than Type Ia (P99).
KeywordsInternal Medicine Inhibition Study Cefaclor Nitrocefin Minimal Ability
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