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European Journal of Clinical Microbiology

, Volume 6, Issue 5, pp 570–571 | Cite as

Beta-lactamase hydrolysis and inhibition studies of the new 1-carbacephem LY163892

  • R. N. Jones
  • A. L. Barry
New Antimicrobial Agents

Abstract

A novel 1-carbacephem, LY163892, was determined to be more stable to plasmid-mediated beta-lactamases than cefaclor. Chromosomal-mediated Type Ia and IVc enzymes destroyed LY163892 at rates ranging from 16 to 93% that of nitrocefin. LY163892 showed minimal ability to inhibit beta-lactamases other than Type Ia (P99).

Keywords

Internal Medicine Inhibition Study Cefaclor Nitrocefin Minimal Ability 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Jones, R. N., Barry, A. L., Thornsberry, C., Wilson, H. W.: In vitro antimicrobial activity evaluation of cefodizime (HR221), a new semisynthetic cephalosporin. Antimicrobial Agents and Chemotherapy 1981, 20: 760–768.PubMedGoogle Scholar
  2. 2.
    Jones, R. N., Thornsberry, C.: Cefotaxime (HR756): a review of the in vitro antimicrobial properties and spectrum of activity. Reviews of Infectious Diseases 1982, 4, Supplement: S300-S315.PubMedGoogle Scholar
  3. 3.
    Neu, H. C.: Antibiotic inactivating enzymes and bacterial resistance. In: Lorian, V. (ed.): Antibiotics in laboratory medicine. Williams and Wilkins, Baltimore, 1986, p. 757–789.Google Scholar
  4. 4.
    Preston, D. A.: Summary of laboratory studies on the antibacterial activity of cefaclor. Postgraduate Medical Journal 1979, 55, Supplement 4: 22–29.Google Scholar
  5. 5.
    Foglesong, M. A., Lamb, J. W., Deetz, J. V.: Stability and blood level determinations of cefaclor, a new oral cephalosporin antibiotic. Antimicrobial Agents and Chemotherapy 1978, 13: 49–52.PubMedGoogle Scholar
  6. 6.
    Leitner, F., Pursiano, T. A., Buck, R. E., Tsae, Y. H., Chisholm, D. R., Misiek, M. Desiderio, J. V., Kessler, R. E.: BMY-28100, a new oral cephalosporin. Antimicrobial Agents and Chemotherapy 1987, 31: 238–243.PubMedGoogle Scholar

Copyright information

© Friedr. Vieweg & Sohn Verlagsgesellschaft mbH 1987

Authors and Affiliations

  • R. N. Jones
    • 1
  • A. L. Barry
    • 1
  1. 1.The Clinical Microbiology InstituteTualatinUSA

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