European Journal of Clinical Microbiology

, Volume 6, Issue 5, pp 570–571 | Cite as

Beta-lactamase hydrolysis and inhibition studies of the new 1-carbacephem LY163892

  • R. N. Jones
  • A. L. Barry
New Antimicrobial Agents


A novel 1-carbacephem, LY163892, was determined to be more stable to plasmid-mediated beta-lactamases than cefaclor. Chromosomal-mediated Type Ia and IVc enzymes destroyed LY163892 at rates ranging from 16 to 93% that of nitrocefin. LY163892 showed minimal ability to inhibit beta-lactamases other than Type Ia (P99).


Internal Medicine Inhibition Study Cefaclor Nitrocefin Minimal Ability 


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Copyright information

© Friedr. Vieweg & Sohn Verlagsgesellschaft mbH 1987

Authors and Affiliations

  • R. N. Jones
    • 1
  • A. L. Barry
    • 1
  1. 1.The Clinical Microbiology InstituteTualatinUSA

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