Abstract
A total of 629 clinical strains of gram positive and gram negative bacteria were tested for their susceptibility to RO 19-5247, RO 15-8074, and other antimicrobial agents. Both RO 19-5247 and RO 15-8074 had good activity against strains of Enterobacteriaceae;however, resistance was found among some strains of Enterobacter, Citrobacter, Klebsiella and Morganella spp. Both compounds showed moderate to poor active against Acinetobacter spp.,Pseudomonas aeruginosa,staphylococci and Streptococcus faecalis.Against strains of Haemophilus influenzae, Neisseria gonorrhoeae, Gardnerella vaginalis, Streptococcus pneumoniae and streptococci (not enterococci), each compound was highly active in vitro. RO 19-5247 and RO 15-8074 had comparable activity to cotrimoxazole, ceftazidime and ceftizoxime. Each new compound had considerably better activity then did cefaclor and amoxicillin/potassium clavulanate.
Similar content being viewed by others
References
National Committee for Clinical Laboratory Standards: Methods for dilution antimicrobial susceptibile tests for bacteria that grow aerobically. M7-A. Villanova, PA, 1985.
Wise, R., Andrews, J. M., Piddock, L. J. V.: In vitro activity of RO 15-8074 and RO 19-5247, two orally administered cephalosporin metabolities. Antimicrobial Agensts and Chemotherapy 1986, 29: 1067–1072.
Peeters, M., Piot, P.: In vitro activity of RO 15-8074, a new oral cephalosporin. Journal of Antimicrobial Chemotherapy 1985, 16: 469–473.
Neu, H. C., Chin, N.-X., Labthavekul, P.: In vitro activity andβ-lactamase stability of two oral cephalosporins, RO 19-5247 and RO 15-8074. Antimicrobial Agents and Chemotherapy 1986, 30: 423–428.
Fass, R. J., Helsel, V. L.: In vitro activities of RO 19-5247 and RO 15-8074, new oral cephalosporins. Antimicrobial Agents and Chemotherapy 1986, 30: 429–434.
Jones, R. N., Fuchs, P. C., Barry, A. L., Ayers, L. W., Gerlach, E. H., Gavan, T. L.: Antimicrobial activity of RO 15-8074, active metabolite of a new oral cephalosporin (RO 15-8075), against 7,775 recent clinical isolates. Antimicrobial Agents and Chemotherapy 1986, 30: 961–963.
Valle, T., Jalanko, E., Scheinin, L., Renkonen, O.-V.: In vitro activity of RO 15-8074 and RO 19-5247. European Journal of Clinical Microbiology 1987, 6: 167–169.
Ng, W. S., Chan, P. Y., Leung, Y. K., Wong, P. C. L.: In vitro activity of RO 15-8074, a new oral cephalosporin, againstNeisseria gonorrhoeae Antimicrobial Agents and Chemotherapy 1985, 28: 461–463.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Aldridge, K.E., Schiro, D.D. & Sanders, C.V. Comparative in vitro activity of the two new oral cephalosporin metabolites RO 19-5247 and RO 15-8074. Eur. J, Clin. Microbiol. 6, 564–569 (1987). https://doi.org/10.1007/BF02014247
Issue Date:
DOI: https://doi.org/10.1007/BF02014247