Abstract
Many of the enterotoxin-producingEscherichia coli strains causing diarrhea in humans possess one of two types of pili adhesins, the colonization factor antigens CFA/I and CFA/II. We identified two subtypes of CFA/II in two CFA/II bearingEscherichia coli strains (serotypes 06∶H16 and 078∶H12) by means of immunodiffusion analyses of heated extracts and hemagglutination inhibition tests. In addition to a shared antigenic structure on CFA/II from both strains, a specific antigenic determinant could be demonstrated on CFA/II from the O6∶H16 strain. A protective effect against intestinal loop challenge with homologous bacteria in rabbits was noted for antibodies to both the shared and the subtype-specific structures of CFA/II.
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Svennerholm, A.M., Åhrén, C. Serological subtypes ofEscherichia coli colonization factor antigen II. Eur. J, Clin. Microbiol. 1, 107–111 (1982). https://doi.org/10.1007/BF02014201
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DOI: https://doi.org/10.1007/BF02014201