Abstract
The effect of oral ciprofloxacin on the intestinal flora was investigated in six male volunteers aged between 21 and 54 years. Faecal specimens were cultured quantitatively for aerobic and anaerobic micro-organisms before, during and after a five day course of ciprofloxacin. Ciprofloxacin resulted in a significant reduction in aerobic flora in all volunteers and colonisation with resistant coagulase-negative staphylococci or corynebacteria in two volunteers. The total anaerobic flora counts were significantly reduced in only one volunteer. NeitherClostridium difficile nor its toxin was detected and there was no significant colonisation withPseudomonas spp. or yeasts; no ciprofloxacin-resistant gram-negative bacilli were detected. Peak serum levels on days 1 and 5 of 1.6–4.3 mg/l (mean 2.7) were achieved after 30–90 min and urine recovery over the five days was 27.1–44.6%.
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References
Alestig, K., Carlberg, H., Nord, C. E., Trollfers, B.: Effect of cefoperazone on faecal flora. Journal of Antimicrobial Chemotherapy 1983, 12: 163–167.
Bodey, G. P., Fainstein, V., Garcia, I., Rosenbaum, B., Wong, Y.: Effect of broad-spectrum cephalosporins on the microbial flora of recipients. Journal of Infectious Diseases 1983, 148: 892–897.
Brumfitt, W., Franklin, I., Grady, D., Hamiltin-Miller, J. M. T., Iliffe, A.: Changes in the pharmacokinetics of ciprofloxacin and faecal flora during administration of a 7-day course to human volunteers. Antimicrobial Agents and Chemotherapy 1984, 26: 757–761.
Reeves, D. S., Bywater, M. J., Holt, H. A., White, L. O.: In-vitro studies with ciprofloxacin, a new 4-quinolone compound. Journal of Antimicrobial Chemotherapy 1984, 13: 333–346.
Kager, L., Malmborg, A. S., Nord, C. E., Sjostedt, S.: Impact of single dose as compared to three dose prophylaxis with latamoxef (moxalactam) on the colonic microflora in patients undergoing colorectal surgery. Journal of Antimicrobial Chemotherapy. 1984, 14: 171–177.
Mulligan, M. E., Citron, D., Gabay, E., Kirby, B. D., George, W. L., Finegold, S. M.: Alterations in human faecal flora, including ingrowth ofClostridium difficile, related to cefoxitin therapy. Antimicrobial Agents and Chemotherapy 1984, 26: 343–346.
Kemmerich, B., Warns, H., Lode, H., Borner, K., Koeppe, P., Knothe, H.: Multiple-dose pharmacokinetics of ceftazidime and its influence on faecal flora. Antimicrobial Agents and Chemotherapy 1983, 24: 333–338.
Heimdahl, A., Nord, C. E., Weilander, K.: Effect of bacampicillin on human mouth, throat and colon flora. Infection 1979, 7, Supplement 5: 446–451.
Guerrant, R. L., Wood, S. J., Krongaard, L., Reid, R. A., Hodge, R. H.: Resistance among faecal flora of patients taking sulphamethoxazole-trimethoprim or trimethoprim alone. Antimicrobial Agents and Chemotherapy 1981, 19: 33–38.
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Holt, H.A., Lewis, D.A., White, L.O. et al. Effect of oral ciprofloxacin on the faecal flora of healthy volunteers. Eur. J, Clin. Microbiol. 5, 201–205 (1986). https://doi.org/10.1007/BF02013987
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DOI: https://doi.org/10.1007/BF02013987