European Journal of Clinical Microbiology

, Volume 2, Issue 5, pp 505–508 | Cite as

A comparison of the pharmacokinetics and tissue penetration of ceftriaxone, moxalactam and cefotaxime

  • R. Wise
  • J. M. Andrews
Current Topic: Ceftriaxone


One gram each of moxalactam and cefotaxime and 0.5 g of ceftriaxone was administered intravenously to six volunteers. The pharmacokinetics and tissue penetration (as measured by a blister fluid model) were studied. The initial (i.e. 15 min) concentrations of the agents were 89.7 mg/l, 101 mg/l and 55 mg/l for ceftriaxone, moxalactam and cefotaxime respectively. The serum half-lives differed considerably, being 8.8, 2.8 and 1.2 h respectively. All agents penetrated the blister fluid rapidly the maximum penetration being found with ceftriaxone, namely 32.7 mg/l.


Internal Medicine Ceftriaxone Cefotaxime Fluid Model Tissue Penetration 
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Copyright information

© Vieweg Publishing 1983

Authors and Affiliations

  • R. Wise
    • 1
  • J. M. Andrews
    • 1
  1. 1.Department of MicrobiologyDudley Road HospitalBirminghamUK

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