A comparison of the pharmacokinetics and tissue penetration of ceftriaxone, moxalactam and cefotaxime
One gram each of moxalactam and cefotaxime and 0.5 g of ceftriaxone was administered intravenously to six volunteers. The pharmacokinetics and tissue penetration (as measured by a blister fluid model) were studied. The initial (i.e. 15 min) concentrations of the agents were 89.7 mg/l, 101 mg/l and 55 mg/l for ceftriaxone, moxalactam and cefotaxime respectively. The serum half-lives differed considerably, being 8.8, 2.8 and 1.2 h respectively. All agents penetrated the blister fluid rapidly the maximum penetration being found with ceftriaxone, namely 32.7 mg/l.
KeywordsInternal Medicine Ceftriaxone Cefotaxime Fluid Model Tissue Penetration
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- 1.Wise, R., Gillett, A. P., Andrews, J. M., Bedford, K. A.: Ro 13-39904: a new cephalosporin with a high degree of activity and broad antibacterial activity: an in vitro comparative study. Journal of Antimicrobial Chemo therapy 1980, 6: 595–600.Google Scholar
- 4.Wise, R., Gillett, A. P., Cadge, B., Durham, S. R., Baker, S.: The influence of protein binding upon tissue fluid levels of 6Β-lactams. Journal of Infectious Diseases 1980, 142: 77–82.Google Scholar
- 5.Gladtke, E., Hattingberg, H. M.: Pharmacokinetics an introduction. Springer, Berlin, 1979.Google Scholar