Skip to main content
SpringerLink
Log in

Single-dose antimicrobial prophylaxis in open heart surgery

  • Published:
European Journal of Clinical Microbiology Aims and scope Submit manuscript

Abstract

A single one-gram pre-operative dose of ceftriaxone was compared with seven one-gram doses of cefazolin administered peri-operatively with the aim of preventing infections associated with coronary artery bypass graft surgery. Ninety-four évaluable cases were analyzed; 49 patients received ceftriaxone and 45 received cefazolin. There was no significant difference in the number of infectious complications between the two groups. Ceftriaxone had a terminal half-life of approximately 15.7 hours. There was no toxicity associated with either antibiotic. Because of the reduced number of doses, single-dose prophylaxis may result in considerable savings. Single-dose prophylaxis with ceftriaxone was found to be an effective modality for prevention of infection in open heart surgery.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Burke, J. F.: The effective period of antibiotic action in experimental incisions and dermal lesions. Surgery 1961, 50: 161–168.

    PubMed  CAS  Google Scholar 

  2. Nichols, R. L.: Use of prophylactic antibiotics in surgical practice. American Journal of Medicine 1981, 70: 686–692.

    Article  PubMed  CAS  Google Scholar 

  3. Ehrenkranz, N. J.: Surgical wound infection occurrence in clean operations. American Journal of Medicine 1981, 70: 909–914.

    Article  PubMed  CAS  Google Scholar 

  4. Kluge, R. M., Calia, F. M., McLaughlin, J. S., Hornick, R. B.: Sources of contamination in open heart surgery. Journal of American Medical Association 1974, 230: 1415–1418.

    Article  CAS  Google Scholar 

  5. Lett, W. J., Ansbacher, R., Davison, B. L., Otterson, W. N.: Prophylactic antibiotics for women undergoing vaginal hysterectomy. Journal of Reproductive Medicine 1977, 19: 51–54.

    PubMed  CAS  Google Scholar 

  6. Mendelson, J., Portnoy, J., DeSaint Victor, J. R., Gelfand, M. M.: Effect of single and multidose cephradine prophylaxis on infectious morbidity of vaginal hysterectomy. Obstetrics and Gynecology 1979, 53: 31–35.

    PubMed  CAS  Google Scholar 

  7. Strachan, C. J. L., Black, J., Powis, S. J. A., Waterworth, T. A., Wise, R., Wilkinson, A. R., Burdon, D. W., Severen, M., Mitra, B., Norcott, H.: Prophylactic use of cephazolin against wound sepsis after cholecystectomy. British Medical Journal 1977, 1: 1254–1256.

    Article  PubMed  CAS  Google Scholar 

  8. Conte, J. E., Jr., Cohen, S. N., Roe, B. B., Elashoff, R. M.: Antibiotic prophylaxis and cardiac surgery: A prospective double blind comparison of single dose versus multiple dose regimens. Annals of Internal Medicine 1972, 76: 943–949.

    PubMed  Google Scholar 

  9. Beam, T. R., Allen, J. C.: Blood, brain and CSF concentrations of several antibiotics in rabbits with intact and inflamed meninges. Antimicrobial Agents and Chemotherapy 1977, 12: 710–716.

    PubMed  CAS  Google Scholar 

  10. Norden, C. W., Kennedy, E.: Experimental osteomyelitis II. Therapeutic trials and measurement of antibiotic levels in bone. Journal of Infectious Diseases 1971, 124: 565–571.

    PubMed  CAS  Google Scholar 

  11. Lowry, O. H., Hastings, A. B.: Histochemical changes associated with aging. Journal of Biological Chemistry 1942, 143: 257–269.

    CAS  Google Scholar 

  12. Beam, T. R., Raab, T. A., Spooner, J. A., Balderman, S. C., Aldridge, J., Bhayana, J. N.: Comparison of ceftriaxone and cefazolin prophylaxis against infection in open heart surgery. American Journal of Surgery (in press).

  13. Austin, T. W., Coles, J. C., Burnett, R., Goldbach, M.: Aortocoronary bypass procedures and sternotomy infections: A study of antistaphylococcal prophylaxis. Canadian Journal of Surgery 1980, 23: 483–485.

    CAS  Google Scholar 

  14. Fong, I. W., Baker, C. B., McKee, D. C.: The value of prophylactic antibiotics in aorta-coronary bypass operations. A double-blind randomized trail. Journal of Thoracic and Cardiovascular Surgery 1979, 78: 908–913.

    PubMed  CAS  Google Scholar 

  15. Wells, F. C., Newsom, S. W. B., Rowlands, C.: Wound infection in cardiothoracic surgery. Lancet 1983, i: 1209–1210.

    Article  Google Scholar 

  16. Farrington, M., Webster, M., Fenn, A., Phillips, I.: Wound infection in cardiothoracic surgery. Lancet 1983, ii: 395–396.

    Article  Google Scholar 

  17. Goldmann, D. A., Hopkins, C. C., Karchmer, A. W., Abel, R. M., McEnany, T., Akins, C., Buckley, M. J., Moellering, R. C.: Cephalothin prophylaxis in cardiac valve surgery. A prospective, double-blind comparison of two-day and six-day regimens. Journal of Thoracic and Cardiovascular Surgery 1977, 73: 470–479.

    PubMed  CAS  Google Scholar 

  18. Polk, R. E., Archer, G. L., Lower, R.: Cefamandole kinetics during cardiopulmonary bypass. Clinical Pharmacology and Therapeutics 1978, 23: 473–480.

    PubMed  CAS  Google Scholar 

  19. William, D. J., Steele, T. W.: Cephalothin prophylaxis assay during cardiopulmonary bypass. Journal of Thoracic and Cardiovascular Surgery 1976, 71: 207–211.

    PubMed  Google Scholar 

  20. Miller, K. W., McCoy, G. G., Chan, K. K. H.: Effect of cardiopulmonary bypass on cefazolin disposition. Clinical Pharmacology and Therapeutics 1980, 27: 550–556.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Infectious Diseases Section, Veterans Administration Medical Center, 3495 Bailey Avenue, 14215, Buffalo, New York, USA

    T. Beam & J. Spooner

  2. Infectious Diseases Section, Mercy Hospital, 565 Abbott Road, 14220, Buffalo, New York, USA

    T. Raab

  3. Cardiothoracic Surgery Section, Veterans Administration Medical Center, 3495 Bailey Avenue, 14215, Buffalo, New York, USA

    S. Balderman, J. Aldridge & J. Bhayana

Authors
  1. T. Beam
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. T. Raab
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. Spooner
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. S. Balderman
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. J. Aldridge
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. J. Bhayana
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Beam, T., Raab, T., Spooner, J. et al. Single-dose antimicrobial prophylaxis in open heart surgery. Eur. J, Clin. Microbiol. 3, 598–604 (1984). https://doi.org/10.1007/BF02013631

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02013631

Keywords

Search

Navigation