Mixed outbreak ofBordetella pertussis andBordetella parapertussis infection in Finland
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The epidemiology of whooping cough in a vaccinated population was studied during an outbreak of paroxysmal cough in an elementary school with 258 pupils in Turku, Finland. Nasopharyngeal specimens for isolation ofBordetella pertussis and/or sera for ELISA detection of antipertussis immunoglobulin M, A and G antibodies were taken from 94 % of children who were prospectively followed for two months.Bordetella pertussis was isolated in six patients, and 17 culture-positive cases withBordetella parapertussis were identified. Patients withBordetella pertussis orBordetella parapertussis were found simultaneously in the same classrooms. Comparison of immunoglobulin M responses toBordetella pertussis andBordetella parapertussis was used for differential diagnosis of these two infections. Twenty-six cases with pertussis and 27 cases with parapertussis were diagnosed. The results of this prospective study suggest thatBordetella parapertussis is a more common etiologic agent of mild respiratory tract infection among vaccinated school-aged children than is generally recognised. The possibility thatBordetella pertussis was converted toBordetella parapertussis during this outbreak is discussed.
KeywordsInternal Medicine Differential Diagnosis Tract Infection Respiratory Tract Respiratory Tract Infection
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- 2.Lautrop, H.: Laboratory diagnosis of whooping-cough orBordetella infections. Bulletin of the World Health Organization 1960, 23: 15–35.Google Scholar
- 5.Kuronen, T., Huovila, R.: Seroresponse to pertussis vaccine. In: Manclark, C. R., Hill, J. C. (ed.): International symposium on pertussis. U.S. Department of Health, Education, and Welfare, Bethesda, MD, 1979, p. 34–40.Google Scholar
- 9.Irons, I. I., MacLennan, A. P.: Isolation of the lymphocytosis promoting factor-hemagglutinin ofBordetella pertussis by affinity chromatography. Biochemica Biophysica Acta 1979, 580: 175–185.Google Scholar
- 17.Kloos, W. E., Dobrogosz, W. J., Ezzell, J. W., Kimbro, B. R., Manclark, C. R.: DNA-DNA hybridization, plasmids and genetic exchange in the genusBordetella. In: Manclark, C. R., Hill, J. C. (ed.): International symposium on pertussis. U.S. Department of Health, Education, and Welfare, Bethesda, MD, 1979, p. 70–80.Google Scholar
- 19.Mebel, S., Lapaeva, I.: Conversion ofBordetella parapertussis serovar through lysogenity produced by pertussis phages. Zentralblatt für Bakteriologie, Mikrobiologie und Hygiene (A) 1982, 252: 547–556.Google Scholar