European Journal of Clinical Microbiology

, Volume 5, Issue 1, pp 93–97 | Cite as

Serum bactericidal titer as a predictor of outcome in endocarditis

  • C. J. Hackbarth
  • H. F. Chambers
  • M. A. Sande
Articles

Abstract

A study was conducted in 89 rabbits with experimental aortic valve endocarditis caused by three different strains ofStaphylococcus aureusto determine whether there was a correlation between the peak serum bactericidal titer of the four drugs tested and the vegetation titer. After four days of therapy both the rabbits with and those without sterile vegetations had median peak bactericidal titers of 1∶8. The mean vegetation titers did not correlate with the mean bactericidal titers. The serum bactericidal test does not measure the relative rate of killing of the bacteria by the drugs. Although the test remains clinically useful for documentation of bactericidal activity, the minimum level of activity necessary for the test to serve as a predictor of outcome remains to be defined.

Keywords

Internal Medicine Bactericidal Activity Aortic Valve Endocarditis Relative Rate 

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Copyright information

© Friedr. Vieweg & Sohn Verlagsgesellschaft mbH 1986

Authors and Affiliations

  • C. J. Hackbarth
    • 1
  • H. F. Chambers
    • 1
  • M. A. Sande
    • 1
    • 2
  1. 1.Department of Medicine, School of MedicineUniversity of CaliforniaSan FranciscoUSA
  2. 2.The Medical ServiceSan Francisco General HospitalSan FranciscoUSA

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