Abstract
Anti-HTLV-III antibody was tested in frozen sera from high-risk individuals, collected between 1974 and 1985 in Switzerland. All but one of the 262 sera of a control group were negative. Among drug addicts, none of the 78 samples collected from 1974 to 1979 was positive. Antibody was first detected in 1980 and thereafter with progressively increasing frequency. Three of 63 samples from 24 dialyzed patients who had received multiple transfusions showed borderline positive values. None of the seropositive subjects has developed AIDS or AIDS-related complex.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Barré-Sinoussi, F., Chermann, J. C., Rey, F., Nugeyre, M. T., Chamaret, S., Gruest, J., Dauguet, C., Axler-Blin, C., Vézinet-Brun, F., Rouzioux, C., Rozenbaum, W., Montagnier, L.: Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS). Science 1983, 220: 868–871.
Popovic, M., Sarngadharan, M. G., Read, E., Gallo, R. C.: Detection, isolation and continuous production of cytopathic retroviruses (HTLV-III) from patients with AIDS and pre-AIDS. Science 1984, 224: 497–500.
Sarngadharan, M. G., Popovic, M., Bruch, L., Schüpbach, J., Gallo, R. R.: Antibodies reactive with human T-lymphotropic retroviruses (HTLV-III) in the serum of patients with AIDS. Science 1984, 224: 506–508.
Laurence, J., Brun-Vézinet, F., Schutzer, S. E., Rouzioux, C., Klatzmann, D., Barré-Sinoussi, F., Chermann, J. C., Montagnier, L.: Lymphadenopathy-associated viral antibody in AIDS. New England Journal of Mediine, 1984, 311: 1269–1273.
Safai, B., Groopman, J. E., Popovic, M., Schüpbach, J., Sarngadharan, M. G., Arnett, K., Sliski, A., Gallo, R. C.: Seroepidemiological studies of human T-lymphotropic retrovirus type III in acquired immunodeficiency syndrome. Lancet 1984, i: 1438–1440.
Schüpbach, J., Haller, O., Vogt, M., Lüthy, R., Joller, H., Oelz, O., Popovic, M., Sarngadharan, M. G., Gallo, R. C.: Antibodies to HTLV-III in Swiss patients with AIDS and pre-AIDS and in a group at risk for AIDS. New England Journal of Medicine 1985, 312: 265–270.
Weiss, S. H., Goedert, J. J., Sarngadharan, M. G., Bodner, A. J., Gallo, R. C., Blattner, W. A.: Screening test for HTLV-III (AIDS Agent) antibodies. Specificity, sensitivity, and applications. Journal of the American Medical Association 1985, 253: 221–225.
Melbye, M., Biggar, R. J., Ebbeson, P., Sarngadharan, M. G., Weiss, S. H., Gallo, R. C., Blattner, W. A.: Sero-epidemiology of HTLV-III antibody in Danish homosexual men: prevalence, transmission, and disease outcome. British Medical Journal 1984, 289: 573–575.
Evatt, B. L., Gomperts, E. D., McDougal, J. S., Ramsey, R. B.: Coincidental appearance of LAV/HTLV-III antibodies in haemophiliacs and the onset of the AIDS epidemic. New England Journal of Medicine 1985, 312: 483–486.
Madhok, R., Melbye, M., Lowe, G. D. O., Forbes, C. D., Froebel, K. S., Bodner, A. J., Biggar, R. J.: HTLV-III antibody in sequential plasma samples from haemophiliacs 1974–1984. Lancet 1985, i: 524–525.
Acquired immune deficiency syndrome (AIDS). WHO Weekly Epidemiological Records 1985, 12: 85–90.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Stroun, J., Graf, I. & Frei, P.C. Detection of Anti-HTLV-III/IAV antibody by enzyme-linked immunosorbent assay in high-risk individuals in Switzerland 1974–1985. Eur. J, Clin. Microbiol. 4, 583–586 (1985). https://doi.org/10.1007/BF02013400
Issue Date:
DOI: https://doi.org/10.1007/BF02013400