Calcified Tissue Research

, Volume 26, Issue 1, pp 103–106 | Cite as

Effect of testosterone therapy on bone formation in an osteoporotic hypogonadal male

  • Daniel T. Baran
  • Michele A. Bergfeld
  • Steven L. Teitelbaum
  • Louis V. Avioli


Osteoporosis has been reported to complicate androgen deficiency in males. Accordingly, we have evaluated an osteoporotic hypogonadal male with bone histomorphometry before and after 6 months of testosterone replacement. Androgen therapy resulted in increases in relative osteoid volum, total osteoid surface, linear extent of bone formation, and bone mineralization. The dramatic histological response to hormonal replacement confirms the importance of androgens in bone modeling and remodeling.

Key words

Osteoporosis Hypogonadism Bone formation Testosterone 


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Copyright information

© Springer-Verlag 1978

Authors and Affiliations

  • Daniel T. Baran
    • 1
  • Michele A. Bergfeld
    • 1
  • Steven L. Teitelbaum
    • 1
  • Louis V. Avioli
    • 1
  1. 1.Departments of Medicine and Pathology, Division of Bone and Mineral Metabolism, Washington University School of MedicineThe Jewish Hospital of St. LouisSt. Louis

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