Summary
Twenty-four hours after a tetracycline injection, the unimpeded, and more rapidly erupting, mouse mandibular incisor contained 20% to 44% more tetracycline than the contralateral, uncut incisor. It was concluded that the increased tetracycline incorporation reflected a higher rate of mineralization associated with faster tooth formation in the unimpeded tooth.
By measuring the amount of tetracycline which became incorporated at different times after an incisor was shortened, it was possible to investigate an early stage of the response of the incisor to cutting. A significant increase in the capacity of the tooth to incorporate tetracycline was detectable 4 h after shortening the tooth, and this was maximal after another 4 h.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Ness, A.R.: Eruption rates of unimpeded and impeded mandibular incisors of the adult laboratory mouse. Arch. Oral Biol.10, 439–451 (1965)
Hawkins, K.I.: Fluorometric determination of demethylchlortetracycline and tetracycline in mammalian bone. Anal. Biochem.45, 128–136 (1972)
Kohn, K.W.: Determination of tetracycline by extraction of fluorescent complexes. Anal. Chem.33, 862–866 (1961)
Ibsen, K.I., Saunders, R.L., Urist, M.: Fluorometric determination of oxytetracycline in biological material. Anal. Biochem.5, 505–514 (1963)
Kelly, R.G., Peets, L.M., Hoyt, K.D.: A fluorometric method of analysis for tetracycline. Anal. Biochem.28, 222–229 (1969)
Steendijk, R.: Studies on the mechanism of the fixation of the tetracycline to bone. Acta Anat. (Basel)56, 368–382 (1964)
Antalovská, Z.: Laws of tetracycline antibiotic deposition in rat incisors. J. Dent. Res.45, 1430–1438 (1966)
Bevelander, G., Nakahara, H.: Correlation between tetracycline binding and mineralisation in dentin and enamel. Anat. Rec.153, 141–148 (1965)
Schour, I., Medak, H.: Experimental increase in rate of eruption and growth of rat incisor by eliminating attrition. J. Dent. Res.30, 521 (Abst.) (1951)
Robins, M.W.: Growth and eruption of the rat incisor. Ph.D. Thesis, University of London, London (1968)
Buyske, D.A., Eisner, H.J., Kelly, R.G.: Concentration and persistence of tetracycline and chlortetracycline in bone. J. Pharmacol. Exp. Ther.130, 150–156 (1960)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Gibson, C.J., Thornton, V.F. & Brown, W.A.B. Incorporation of tetracycline into impeded and unimpeded mandibular incisors of the mouse. Calc. Tis Res. 26, 29–31 (1978). https://doi.org/10.1007/BF02013230
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02013230