Skip to main content
Log in

Mean wall thickness of trabecular bone packets in the human iliac crest: Changes with age

  • Published:
Calcified Tissue Research Aims and scope Submit manuscript

Summary

The mean wall thickness (MWT) of packets of trabecular bone was measured in undecalcified iliac crest bone samples of 36 normal subjects (14 female and 22 male) under polarized light. The mean wall thickness was 49.7±8.7 μm at a mean age of 50.9 years. There existed a significant decrease of MWT with advancing age. With an appositional rate of 0.72 μm/day, the mean formation time of iliac trabecular bone packets is 69 days. The decrease of MWT with age corresponds to a decrease in bone formation at the basic multicellular unit (BMU) level with aging and can partly explain the physiological senile osteopenia.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Wakamatsu, E., Sissons, H.A.: The cancellous bone of the iliac crest. Calcif. Tissue Res.4, 147–161 (1969)

    PubMed  Google Scholar 

  2. Merz, W.A., Schenk, R.K.: Quantitative structural analysis of human cancellous bone. Acta Anat. (Basel)75, 54–66 (1970)

    Google Scholar 

  3. Bordier, Ph.J., Tun Chot, S.: Quantitative histology of metabolic bone disease. Clin Endocrinol. Metab.1 (1), 197–215 (1972)

    Google Scholar 

  4. Meunier, P.J., Courpron, P., Edouard, C., Bernard, J., Bringuier, J., Vignon, G.: Physiological senile involution and pathological rarefaction of bone. Clin. Endocrinol. Metab.2, 239–256 (1973)

    PubMed  Google Scholar 

  5. Taylor, Th.C., Epker, B.N., Frost, H.M.: The appositional rate of haversian and endosteal bone formation measured in tetracycline-labeled human ribs. J. Lab. Clin. Med.67, 633–639 (1966)

    Google Scholar 

  6. Merz, W.A., Schenk, R.K.: A quantitative histological study on bone formation in human cancellous bone. Acta Anat. (Basel)76, 1–15 (1970)

    Google Scholar 

  7. Meunier, P.J., Edouard, C., Courpron, P., Toussaint, F.: Morphometric analysis of osteoid in iliac trabecular bone. Methodology. Dynamical significance of the osteoid parameters. In: Vitamin D and problems related to uremic bone disease (Norman, A.W., ed.), p. 149–155. Berlin-New York: Walter de Gruyter 1975

    Google Scholar 

  8. Frost, H.M.: Mean formation time of human osteons. Can. J. Biochem. Physiol.41, 1307–1310 (1963)

    PubMed  Google Scholar 

  9. Frost, H.M.: Tetracycline-based histological analysis of bone remodelling. Calcif. Tissue Res.3, 211–237 (1969)

    PubMed  Google Scholar 

  10. Frost, H.M.: Bone dynamics in metabolic bone disease. J. Bone Joint Surg.48A, 1192–1203 (1966)

    Google Scholar 

  11. Sedlin, E.D., Frost, H.M., Villanueva, A.R.: Variations in cross section area of rib cortex with age. J. Gerontol.18, 9–13 (1963)

    PubMed  Google Scholar 

  12. Courpron, P., Meunier, P.J., Edouard, C., Bernard, J., Bringuier, J., Vignon, G.: Données histologiques quantitatives sur le vieillissement osseux humain. Rev. Rhum. Mal. Osteoartic.40, 469–483 (1973)

    PubMed  Google Scholar 

  13. Frost, H.M.: Histomorphometry of trabecular bone: a theoretical correction of appositional rate measurements. In: Bone Histomorphometry 1976. Proceedings of the Second International Workshop (Meunier, P.J., ed.) pp. 361–370. Paris: Armour Montagu 1977

    Google Scholar 

  14. Meunier, P.J.: Disturbances in morphology and dynamics of the remodelling process in pagetic bone. In: Human calcitonin and Paget's disease. Proceedings of an international workshop. (MacIntyre, I., ed.), pp. 78–89. Bern: Hans Huber Publishers 1977

    Google Scholar 

  15. Jett, S., Wu, K., Frost, H.M.: Tetracycline-based histological measurement of cortical endosteal bone formation in normal and osteoporotic rib. Henry Ford Hosp. Med. J.15, 325–344 (1967)

    Google Scholar 

  16. Schenk, R.K., Merz, W.A., Müller, J.: A quantitative histological study on bone resorption in human cancellous bone. Acta Anat. (Basel)74, 44–53 (1969)

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Additional information

This work was partly supported by Faculté Alexis Carrel, Lyon, France.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lips, P., Courpron, P. & Meunier, P.J. Mean wall thickness of trabecular bone packets in the human iliac crest: Changes with age. Calc. Tis Res. 26, 13–17 (1978). https://doi.org/10.1007/BF02013227

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02013227

Key words

Navigation