European Journal of Clinical Microbiology

, Volume 6, Issue 4, pp 502–503 | Cite as

Antibiotic interaction: Interpretation of fractional inhibitory and fractional bactericidal concentration indices

  • A. M. Horrevorts
  • M. F. Michel
  • K. F. Kerrebijn
Letters to the Editor


Internal Medicine Concentration Index Antibiotic Interaction Fractional Bactericidal Concentration 


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    Woolfrey, B. F., Fox, J. M. K., Lally, R. T., Quail, C. O.: Broth microdilution testing ofPseudomonas aeruginosa and aminoglycosides: need for employing dilutions differing by small arithmetic increments. Journal of Clinical Microbiology 1982, 16: 663–667.PubMedGoogle Scholar
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    Horrevorts, A. M., de Ridder, C. M., Pool, M. C., de Jonge, M. J. A., Degener, J. E., Dzoljic-Danilovic, G., Michel, M. F., Kerrebijn, M. F.: Checkerboard titrations: the influence of the composition of serial dilutions of antibiotics on the fractional inhibitory concentration index and fractional bactericidal concentration index. Journal of Antimicrobial Chemotherapy 1987, 19: 119–125.PubMedGoogle Scholar
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    Berenbaum, M. C.: A method for testing for synergy with any number of agents. Journal of Infectious Diseases 1978, 137: 122–130.PubMedGoogle Scholar
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    Hamilton-Miller, J. M. T.: Rationalization of terminology and methodology in the study of antibiotic interaction. Journal of Antimicrobial Chemotherapy 1985, 15: 655–658.PubMedGoogle Scholar

Copyright information

© Friedr. Vieweg & Sohn Verlagsgesellschaft mbH 1987

Authors and Affiliations

  • A. M. Horrevorts
    • 1
  • M. F. Michel
    • 1
  • K. F. Kerrebijn
    • 2
  1. 1.Department of Clinical Microbiology and Antimicrobial TherapyErasmus UniversityDR RotterdamThe Netherlands
  2. 2.Department of Respiratory Diseases in ChildrenErasmus UniversityDR RotterdamThe Netherlands

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