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European Journal of Clinical Microbiology

, Volume 6, Issue 4, pp 482–485 | Cite as

Comparative in vitro activity of RO 23-6240 (Fleroxacin), a new 4-quinolone derivative

  • K. Machka
  • I. Braveny
New Antimicrobial Agents

Abstract

The in vitro activity of RO 23-6240 was compared with that of norfloxacin, ofloxacin and ciprofloxacin as well as four other antimicrobial agents against 345 recent clinical isolates. The MICs of RO 23-6240 againstEnterobacteriaceae andAcinetobacter anitratum was ⩽0.5mg/l. At the same concentration of the compound 90% of staphylococci were inhibited. AgainstEnterococcm faecalis andPseudomonas aeruginosa RO 23-6240 proved less active, having MIC90 values of 4.0 mg/l and 8.0 mg/l, respectively.Enterobacteriaceae and staphylococci strains that were resistant to piperacillin, cefotaxime or tobramycin were susceptible to the compound. In general the activity of RO 23-6240 was comparable to those of norfloxacin and ofloxacin, but less than that of ciprofloxacin.

Keywords

Internal Medicine Antimicrobial Agent Clinical Isolate Cefotaxime Ofloxacin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Friedr. Vieweg & Sohn Verlagsgesellschaft mbH 1987

Authors and Affiliations

  • K. Machka
    • 1
  • I. Braveny
    • 1
  1. 1.Institute of Medical MicrobiologyTechnical University of MunichMunich 80FRG

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