European Journal of Clinical Microbiology

, Volume 6, Issue 4, pp 482–485 | Cite as

Comparative in vitro activity of RO 23-6240 (Fleroxacin), a new 4-quinolone derivative

  • K. Machka
  • I. Braveny
New Antimicrobial Agents


The in vitro activity of RO 23-6240 was compared with that of norfloxacin, ofloxacin and ciprofloxacin as well as four other antimicrobial agents against 345 recent clinical isolates. The MICs of RO 23-6240 againstEnterobacteriaceae andAcinetobacter anitratum was ⩽0.5mg/l. At the same concentration of the compound 90% of staphylococci were inhibited. AgainstEnterococcm faecalis andPseudomonas aeruginosa RO 23-6240 proved less active, having MIC90 values of 4.0 mg/l and 8.0 mg/l, respectively.Enterobacteriaceae and staphylococci strains that were resistant to piperacillin, cefotaxime or tobramycin were susceptible to the compound. In general the activity of RO 23-6240 was comparable to those of norfloxacin and ofloxacin, but less than that of ciprofloxacin.


Internal Medicine Antimicrobial Agent Clinical Isolate Cefotaxime Ofloxacin 
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Copyright information

© Friedr. Vieweg & Sohn Verlagsgesellschaft mbH 1987

Authors and Affiliations

  • K. Machka
    • 1
  • I. Braveny
    • 1
  1. 1.Institute of Medical MicrobiologyTechnical University of MunichMunich 80FRG

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