Comparative in vitro activity of RO 23-6240 (Fleroxacin), a new 4-quinolone derivative
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The in vitro activity of RO 23-6240 was compared with that of norfloxacin, ofloxacin and ciprofloxacin as well as four other antimicrobial agents against 345 recent clinical isolates. The MICs of RO 23-6240 againstEnterobacteriaceae andAcinetobacter anitratum was ⩽0.5mg/l. At the same concentration of the compound 90% of staphylococci were inhibited. AgainstEnterococcm faecalis andPseudomonas aeruginosa RO 23-6240 proved less active, having MIC90 values of 4.0 mg/l and 8.0 mg/l, respectively.Enterobacteriaceae and staphylococci strains that were resistant to piperacillin, cefotaxime or tobramycin were susceptible to the compound. In general the activity of RO 23-6240 was comparable to those of norfloxacin and ofloxacin, but less than that of ciprofloxacin.
KeywordsInternal Medicine Antimicrobial Agent Clinical Isolate Cefotaxime Ofloxacin
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- 1.Chin, N., Brittain, D. C., Neu, H. C.: In vitro activity of RO 23-6240, a new fluorinated 4-quinolone. Antimicro-bial Agents and Chemotherapy 1986, 29: 675–680.Google Scholar