Skip to main content

Advertisement

SpringerLink
Log in

Beta-lactamase alteration of betalactam inhibitory zones

  • Notes
  • Current Topic Inducible Beta-Lactamases: Enzymes of Increasing Clinical Importance
  • Published:
European Journal of Clinical Microbiology Aims and scope Submit manuscript

Abstract

A disk approximation test, in which the inhibitory zone of one beta-lactam antibiotic is truncated under influence of another beta-lactam (e.g. cefoxitin), was used as a screen for the presence of inducible betalactamase. By using beta-lactamase extracts and a specific inhibitor, it was shown that chromosomal beta-lactamase can indeed be the sole cause of truncated beta-lactam inhibitory zones.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Sanders, C. C., Sanders, W. E., Jr.: Emergence of resistance during therapy with the newerβ-lactam antibiotics: role of inducibleβ-lactamase and implications for the future. Reviews of Infectious Disease 1983, 5: 639–648.

    PubMed  Google Scholar 

  2. Minami, S., Yotsuji, A., Inoue, M., Mitsuhashi, S.: Induction ofβ-lactamase by variousβ-lactam antibiotics inEnterobacter cloacae. Antimicrobial Agents and Chemotherapy 1980, 18: 382–385.

    PubMed  Google Scholar 

  3. Fu, K. P., Neu, H. C.: The role of inducible beta-lactamase in the antagonism seen with certain cephalqsporin combinations. Journal of Antimicrobial Chemotherapy 1981, 7: 104–107.

    PubMed  Google Scholar 

  4. Tausk, F., Evans, M. E., Patterson, L. S., Federspiel, C. F., Stratton, C. W.: Imipenem-induced resistance to antipseudomonalβ-lactams inPseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy 1985, 28: 41–45.

    PubMed  Google Scholar 

  5. Kuck, N. A., Testa, R. T., Forbes, M.: In-vitro and in-vivo antibacterial effects of combinations ofβ-lactam antibiotics. Antimicrobial Agents and Chemotherapy 1981, 19: 634–638.

    PubMed  Google Scholar 

  6. Jacobs, J. Y., Livermore, D. M., Davy, K. W. M.:Pseudomonas aeruginosa, β-lactamase as a defense against azlocillin, mezlocillin and piperacillin. Journal of Antimicrobial Chemotherapy 1984, 14: 221–229.

    PubMed  Google Scholar 

  7. Lowry, O. H., Rosebrough, N. J., Farr, A. L., Randall, R. J.: Protein measurement with the folin phenol reagent. Journal of Biological Chemistry 1951, 193: 265–275.

    PubMed  Google Scholar 

  8. Goering, R. V., Sanders, C. C., Sanders, W. E., Jr.: Antagonism of carbenicillin and ccfamandole by cefoxitin in treatment of experimental infections in mice. Antimicrobial Agents and Chemotherapy 1982, 21: 963–967.

    PubMed  Google Scholar 

  9. Young, L. S.: Doubleβ-lactam therapy in the immunocompromised host. Journal of Antimicrobial Chemotherapy 1985, 16: 4–5.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology, Vanderbilt University School of Medicine, 37232, Nashville, Tennessee, USA

    F. Tausk & C. W. Stratton

Authors
  1. F. Tausk
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C. W. Stratton
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Tausk, F., Stratton, C.W. Beta-lactamase alteration of betalactam inhibitory zones. Eur. J, Clin. Microbiol. 6, 474–476 (1987). https://doi.org/10.1007/BF02013113

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02013113

Keywords

Search

Navigation