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Effect of BMY-28100, a new cephalosporin, onStaphylococcus aureus nasal carriage

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Abstract

In order to examine the in vivo activity of BMY-28100, serial quantitative nasal cultures were taken from 52 nasal carriers of Staphylococcus aureus following administration of the antimicrobial. Nasal carriage rates and mean log titers decreased significantly during (days 2–4 and 5–8) and following (days 1–2 and 6–7) treatment. No change in antibiotic sensitivities was noted in follow-up isolates, and the MIC90 remained at 2mcg/ml. BMY-28100 demonstrated good in vivo activity against Staphylococcus aureus.

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References

  1. Williams, R. E. O.: Healthy carriage ofStaphylococcus aureus: its prevalence and importance. Bacteriological Reviews 1963, 27: 56–71.

    PubMed  Google Scholar 

  2. Martin, R. R., White, A.: Quantitative nasal culture: a tool in antibiotic research. Applied Microbiology 1971, 22: 397–400.

    PubMed  Google Scholar 

  3. Wilson, S. Z., Martin, R. R., Putnam, M.: In vivo effects of josamycin, erythromycin, and placebo therapy on nasal carriage ofStaphylococcus aureus. Antimicrobial Agents and Chemotherapy 1977, 11: 407–410.

    PubMed  Google Scholar 

  4. Wilson, S. Z., Martin, R. R., Putnam, M., Greenberg, S. B., Wallace, R. J., Jr., Jemsek, J.G.: Quantitative nasal cultures from carriers ofStaphylococcus aureus: effects of oral therapy with erythromycin, rosamicin, and placebo. Antimicrobial Agents and Chemotherapy 1979, 15: 379–383.

    PubMed  Google Scholar 

  5. White, A., Hemmerly, T., Martin, M. P., Knight, V.: Studies on the origin of drug-resistant staphylococci in a mental hospital. American Journal of Medicine 1959, 27: 26–39.

    PubMed  Google Scholar 

  6. Colton, T.: Statistics in medicine. Little, Brown, and Company, Boston, 1974, p. 75–76.

    Google Scholar 

  7. Ehrenkranz, N. J.: Person-to-person transmission ofStaphylococcus aureus: quantitative characterization of nasal carriers spreading infection. New England Journal of Medicine 1964, 271: 225–230.

    PubMed  Google Scholar 

  8. Martin, R. R., White, A.: The reacquisition of staphylococci by treated carriers: a demonstration of bacterial interference. Journal of Laboratory and Clinical Medicine 1968,71: 791–797.

    PubMed  Google Scholar 

  9. White, A.: The use of gentamicin as a nasal ointment. American Journal of Medical Sciences 1964, 248: 86–89.

    Google Scholar 

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Authors and Affiliations

  1. Division of General Internal Medicine, Department of Medicine, Baylor College of Medicine, One Baylor Plaza, 77030, Houston, Texas, USA

    R. L. Atmar, M. L. Allen, J. Freiman, C. Kiefe, S. Ehrman & S. B. Greenberg

  2. Department of Microbiology and Immunology, Baylor College of Medicine, One Baylor Plaza, 77030, Houston, Texas, USA

    S. B. Greenberg

Authors
  1. R. L. Atmar
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  2. M. L. Allen
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  3. J. Freiman
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  4. C. Kiefe
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  5. S. Ehrman
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  6. S. B. Greenberg
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Atmar, R.L., Allen, M.L., Freiman, J. et al. Effect of BMY-28100, a new cephalosporin, onStaphylococcus aureus nasal carriage. Eur. J, Clin. Microbiol. 6, 679–681 (1987). https://doi.org/10.1007/BF02013070

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  • DOI: https://doi.org/10.1007/BF02013070

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