Abstract
Over 200 children with acquired immunodeficiency syndrome (AIDS) have been followed at our institution. We retrospectively evaluated 45 children from the above group. 26 of the 45 children had a pericardial effusion documented at echocardiography and/or at post-mortem examination. This report describes the association of pericardial effusion, myocarditis, and pericarditis in children with AIDS and the implications for imaging. Half of the children with a pericardial effusion had a normal cardiac silhouette on chest radiography. 18 children with a pericardial effusion, had associated cardiac abnormalities. These abnormalities were ventricular dilatation and/or hypertrophy, myocarditis, or pericarditis. The presence of pericardial effusion also correlated highly with pleural effusion and ascites. The presence of a pleural effusion and a pericardial effusion was almost exclusively seen in the children with cardiac abnormalities. Pericardial effusion and cardiac disease should not only be suspected in any child with radiographic signs of cardiomegaly, but be strongly suspected in any child with pleural effusions or ascites, even with a normal cardiac silhouette, especially if they are not responding to conventional medical therapy and their respiratory condition is not improving.
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References
Fink L, Reichek N, St John Sutton MG (1984) Cardiac abnormalities in acquired immune deficiency syndrome. Am J Cardiol 54: 1161–1163
Steinherz LJ, Brochstein JA, Robins J (1986) Cardiac involvement in congenital acquired immunodeficiency syndrome. AJDC 140: 1241–1244
Lipshultz SE, Chanock S, Sanders SP, Colan SD, Perez-Atayde A, McIntosh K (1989) Cardiovascular manifestations of human immunodeficiency virus infection in infants and children. Am J Cardiol 63: 1489–1497.
Roldan EO, Moskowitz L, Hensley GT (1987) Pathology of the heart in acquired immunodeficiency syndrome. Arch Pathol Lab Med 111: 943–946
Monsuez JJ, Kinney EL, Vittecoq D, et al (1988) Comparison among acquired immune deficiency syndrome patients with and without clinical evidence of cardiac disease. Am J Cardiol 62: 1311–1313
Corboy JR, Fink L, Miller WT (1987) Congestive cardiomyopathy in association with AIDS. Radiology 165: 139–141
Anderson DW, Virmani R, Reilly JM, et al (1988) Prevalent myocarditis at necropsy in the acquired immunodeficiency syndrome. J Am Coll Cardiol 11: 792–799
Baroldi G, Corallo S, Moroni M et al (1988) Focal lymphocytic myocarditis in acquired immunodeficiency syndrome (AIDS): a correlative morphologic and clinical study in 26 consecutive fatal cases. J Am Coll Cardiol 19: 69–73
Joshi VV, Gadol C, Connor E, Oleske JM, Mendelson J, Marin-Garcia J (1988) Dilated cardiomyopathy in children with acquired immunodeficiency syndrome. Hum Pathol 19: 69–73.
Stewart JM, Aditya K, Gromisch DS, Reyes E, Woolf PK, Gowitz MH (1989) Symptomatic cardiac dysfunction in children with human immunodeficiency virus infection. Am Heart J 117: 140–144
Grody WW, Cheng L, Lewis W (1990) Infection of the heart by the human immunodeficiency virus. Am J Cardiol 66: 203–206
Lipschultz SE, Fox CH, Perez-Atayde AR, et al (1990) Identification of the human immunodeficiency virus-1 and DNA in the heart of a child with cardiovascular abnormalities and congenital acquired immune deficiency syndrome. Am J Cardiol 66: 246–250
Dworkin BM, Antonecchia PP, Smith F et al (1989) Reduced cardiac selenium in the acquired immunodeficiency syndrome. J Parenter Enteral Nutr 13: 644–647
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Mast, H.L., Haller, J.O., Schiller, M.S. et al. Pericardial effusion and its relationship to cardiac disease in children with acquired immunodeficiency syndrome. Pediatr Radiol 22, 548–551 (1992). https://doi.org/10.1007/BF02013013
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DOI: https://doi.org/10.1007/BF02013013