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Calcified Tissue Research

, Volume 23, Issue 1, pp 303–305 | Cite as

Preliminary studies on the binding of plasma albumin to bone tissue

  • J. T. Triffitt
  • Maureen Owen
Article

Summary

The extractability of125I-labelled plasma albumin from bone pieces and from powdered bone has been compared after both in vivo and in vitro incorporation. The results show that albumin is more readily extracted from bone pieces than from bone powder which implies that tissue disruption exposes additional protein adsorption sites. It is suggested that incorporation of plasma albumin into calcified matrix during bone formation occurs mainly as a result of its strong interaction with bone mineral.

Key words

Albumin Bone Hydroxyapatite Plasma protein 

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References

  1. Ashton, B.A., Triffitt, J.T., Höhling, H.J.: Plasma proteins present in human cortical bone: Enrichment of the α2-glycoprotein. Calc. Tiss. Res.22 27–33 (1976)CrossRefGoogle Scholar
  2. Blumenthal, N.C., Betts, F., Posner, A.S.: Effect of carbonate and biological macromolecules on formation and properties of hydroxyapatite. Calc. Tiss. Res.18, 81–90 (1975)Google Scholar
  3. Owen, M.E., Triffitt, J.T., Melick, R.: Albumin in bone. Ciba Fdn. Symp.11, 263–293 (1973)Google Scholar
  4. Owen, M.E., Triffitt, J.T.: Extravascular albumin in bone tissue. J. Physiol.257, 293–307 (1976)PubMedGoogle Scholar
  5. Owen, M.E., Howlett, C.R., Triffitt, J.T.: Movement of125I albumin and125I-polyvinylpyrollidone through bone tissue fluid. Calc. Tiss. Res. In PressGoogle Scholar
  6. Posner, A.S.: Crystal chemistry of bone mineral. Physiol. Rev.49, 760–792 (1969)PubMedGoogle Scholar

Copyright information

© Springer-Verlag 1977

Authors and Affiliations

  • J. T. Triffitt
    • 1
  • Maureen Owen
    • 1
  1. 1.Bone Research Laboratory, Nuffield Department of Orthopaedic SurgeryUniversity of Oxford, Nuffield Orthopaedic CentreOxfordUK

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