Calcified Tissue Research

, Volume 23, Issue 1, pp 121–124 | Cite as

The effect of induced metabolic acidosis on vitamin D3 metabolism in rachitic chicks

  • B. Sauveur
  • M. Garabedian
  • C. Fellot
  • P. Mongin
  • S. Balsan


The metabolism of vitamin D3 was studied in 3-week-old, vitamin D deficient chicks, fed since hatching with a diet containing 3% ammonium chloride, 1% calcium, and 0.7% phosphorus. When kidney homogenates were incubated in vitro with [3H]25-(OH)D3, the production of 1,25-(OH)2D3 was reduced by 40% in acidotic birds. During in vivo experiments, after injection of [3H]D3 (1220 pM/bird), the level of 1,25-(OH)2D3 was also reduced in blood plasma, intestine, and tibiae in acidotic chicks as compared with the controls. As a large increase in plasma phosphate was found during acidosis, these results are discussed in relation to the possible role of phosphorus in the control of 1,25-(OH)2D3 synthesis.

Key words

Vitamin D Metabolic acidosis Phosphorus 


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Copyright information

© Springer-Verlag 1977

Authors and Affiliations

  • B. Sauveur
    • 1
  • M. Garabedian
    • 2
  • C. Fellot
    • 2
  • P. Mongin
    • 1
  • S. Balsan
    • 2
  1. 1.Station de Recherches AvicolesI.N.R.A. NouzillyMonnaieFrance
  2. 2.Laboratoire des Tissus Calcifiés (C.N.R.S.)Hôpital des Enfants MaladesParisFrance

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